Analytical procedures to detect 2,3,7,8-TCDD at Seveso after the industrial accident of July 10, 1976

Ecotoxicology and Environmental Safety
F CattabeniF Merli

Abstract

The analytical procedures used at Seveso (Milan, Italy) for the determination of 2,3,7,8-TCDD, and some isomers, in biological and environmental samples are reviewed in this paper. During the emergency period, up until the first 10 days of August, the extracts, mostly from soil or vegetation samples, were evaporated to dryness and then mixed with less than or equal to 10-ml solvent. Of these solutions, aliquots up to 10 microliter were injected into a low-resolution gas chromatograph (GC) combined with a low-resolution mass spectrometer (MS). Analytical sensitivity for vegetation and soil was less than 10 ppb and approximately 100 ppt, respectively--sufficient for the early mapping of the most heavily contaminated territory. After the emergency period, the greatest improvement in environmental sample analysis was the introduction of cleanup procedure which greatly reduced the presence of unwanted material in samples. Cleanup was followed by the complete removal of the solvent. Dry samples could be taken up with rather small volumes (greater than or equal to 0.1 ml) of solvent, of which an aliquot was used for GC-MS analysis. The instrumental setup was kept as above. For animal samples, extraction entailed preliminary alkaline d...Continue Reading

References

Jan 1, 1979·The Annals of Occupational Hygiene·E HombergerH K Wipf
Jan 1, 1982·Drug Metabolism Reviews·R FanelliA Bonaccorsi
Jun 1, 1980·Bulletin of Environmental Contamination and Toxicology·R FanelliC Sbarra
Jan 1, 1980·Archives of Environmental Contamination and Toxicology·R FanelliF Pezza
Sep 1, 1980·Ecotoxicology and Environmental Safety·A di DomenicoG Zapponi
Dec 1, 1977·Disasters·A M Hay

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Citations

Oct 1, 1989·Ecotoxicology and Environmental Safety·S CerlesiS Ratti
May 26, 1998·Environmental Health Perspectives·P A BertazziA C Pesatori

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