Analytical steady-state solution to the rapid buffering approximation near an open Ca2+ channel

Biophysical Journal
G D Smith

Abstract

We derive an analytical steady-state solution for the Ca2+ profile near an open Ca2+ channel based on a transport equation which describes the buffered diffusion of Ca2+ in the presence of rapid stationary and mobile Ca2+ buffers (Wagner and Keizer, 1994). This steady-state rapid buffering approximation gives an upper bound on local Ca2+ elevations such as Ca2+ puffs or sparks when conditions for the validity of the rapid buffering approximation are met and is an alternative to approximations that assume that mobile buffers are unsaturable. This result also provides an analytical estimate of the cytosolic Ca2+ domain concentration ([Ca2+]d) near a channel pore and shows the dependence of [Ca2+]d on moderate concentrations of endogenous mobile buffer, Ca2+ indicator dye, and bulk cytosolic Ca2+. Assuming a simple relationship between [Ca2+]d and the lumenal depletion domain of an intracellular Ca2+ channel, lumenal and cytosolic Ca2+ profiles are matched to give an implicit analytical expression for the effect of bulk lumenal Ca2+ on [Ca2+]d.

Citations

Jun 23, 2006·Journal of Mathematical Biology·Jong-Shenq Guo, Je-Chiang Tsai
May 15, 2004·Progress in Biophysics and Molecular Biology·Christian Soeller, Mark B Cannell
Nov 17, 2010·The Journal of General Physiology·Horia VaisDon-On Daniel Mak
Nov 14, 2012·The Journal of General Physiology·Horia VaisDon-On Daniel Mak
Nov 19, 2010·PLoS Computational Biology·Yoshihisa Kubota, M Neal Waxham
Oct 2, 2009·Chaos·D SwaminathanP Jung
Oct 10, 2015·The European Journal of Neuroscience·Guobin BaoDetlev Schild
Jun 12, 2012·Cell Calcium·Ghanim UllahJohn E Pearson
Oct 29, 2015·The Journal of Physiology·Calum WilsonJohn G McCarron
Dec 24, 1997·The Journal of Physiology·P Thomas, D W Waring
Oct 31, 2006·Cell Calcium·John G McCarronThomas C Muir
Mar 25, 2008·Biophysical Journal·Jeffrey R Groff, Gregory D Smith
Jun 19, 2013·Biochimica Et Biophysica Acta·Andy K M Lam, Antony Galione
Apr 25, 2000·Biophysical Journal·M R BennettW G Gibson
Nov 19, 2014·Frontiers in Genetics·Frederic von WegnerRainer H A Fink
Mar 17, 2017·The Journal of Chemical Physics·Lorena SigautSilvina Ponce Dawson
Feb 6, 2003·Journal of the American Academy of Nurse Practitioners·Mary Gerner Woltjen
Aug 16, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Alejandra C VenturaSilvina Ponce Dawson
May 15, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Damián E StrierSilvina Ponce Dawson
Jan 17, 2019·Nature Reviews. Neuroscience·Jeremy S Dittman, Timothy A Ryan
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Yasutaka KurataToshishige Shibamoto
May 7, 2020·Journal of Bioinformatics and Computational Biology·Parvaiz Ahmad Naik, Jian Zu
Nov 25, 2016·Interdisciplinary Sciences, Computational Life Sciences·Brajesh Kumar JhaDevanshi D Dave
Feb 1, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rachel Lees-GreenLeo K Cheng
Mar 19, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Emiliano Pérez Ipiña, Silvina Ponce Dawson
Nov 11, 2020·Interdisciplinary Sciences, Computational Life Sciences·Devanshi D Dave, Brajesh Kumar Jha
Nov 13, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·G SoloveyS Ponce Dawson
Nov 14, 1997·The American Journal of Physiology·M E Kargacin, G J Kargacin
Mar 28, 2021·Biophysical Journal·Yinbo Chen, Victor Matveev
Oct 28, 2006·Cell Calcium·Martin OheimWalter Stühmer

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