PMID: 15244851Jul 13, 2004Paper

Analytical study of the effect of recombination on evolution via DNA shuffling

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Weiqun PengDavid A Kessler

Abstract

DNA shuffling is an evolutionary protocol wherein cycles of selection, recombination, mutation, and amplification are employed to evolve proteins and DNA sequences. Experiments have shown its superiority to traditional protocols which do not employ recombination. Motivated by DNA shuffling, we investigate a multilocus evolutionary model that incorporates selection, recombination, and point mutations. Due to simplicity of the model, for the case of an infinite population we can obtain a full analytical treatment of both its dynamical and equilibrium properties, and study the benefit of recombination explicitly and quantitatively. We also briefly discuss finite-population size corrections.

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Citations

Dec 15, 2015·Genome Biology and Evolution·Alexander E LobkovskyEugene V Koonin
Oct 26, 2005·Physical Review Letters·Morten Kloster
Aug 16, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Arne TraulsenChristoph Hauert
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Manuel DehnertMarc-Thorsten Hütt
Apr 18, 2021·Physical Review. E·Moupriya Das, Holger Kantz

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