Analytical techniques for characterization of cyclodextrin complexes in the solid state: A review
Abstract
Cyclodextrins are cyclic oligosaccharides able to form inclusion complexes with a variety of hydrophobic guest molecules, positively modifying their physicochemical properties. A thorough analytical characterization of cyclodextrin complexes is of fundamental importance to provide an adequate support in selection of the most suitable cyclodextrin for each guest molecule, and also in view of possible future patenting and marketing of drug-cyclodextrin formulations. The demonstration of the actual formation of a drug-cyclodextrin inclusion complex in solution does not guarantee its existence also in the solid state. Moreover, the technique used to prepare the solid complex can strongly influence the properties of the final product. Therefore, an appropriate characterization of the drug-cyclodextrin solid systems obtained has also a key role in driving in the choice of the most effective preparation method, able to maximize host-guest interactions. The analytical characterization of drug-cyclodextrin solid systems and the assessment of the actual inclusion complex formation is not a simple task and involves the combined use of several analytical techniques, whose results have to be evaluated together. The objective of the present ...Continue Reading
References
Investigation of the effects of grinding and co-grinding on physicochemical properties of glisentide
Physicochemical characterization and dissolution properties of meloxicam-cyclodextrin binary systems
Carotenoids and β-cyclodextrin inclusion complexes: Raman spectroscopy and theoretical investigation
Spray-dried voriconazole-cyclodextrin complexes: solubility, dissolution rate and chemical stability
Citations
Supercritical Carbon Dioxide as a Green Alternative to Achieve Drug Complexation with Cyclodextrins.
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