Analyzing Circle of Willis blood flow in ischemic stroke patients through 3D Stroke Arterial Flow Estimation

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
Aichi Chien, Fernando Viñuela

Abstract

Background The objective of ischemic stroke (IS) treatment is to achieve revascularization in cerebral arteries to restore blood flow. However, there is no available method to extract arterial flow data from clinical CTA images. We developed 3D Stroke Arterial Flow Estimation (SAFE), which provides blood flow data throughout the Circle of Willis based on 3D CTA and allows comparison of arterial flow distribution in the brain. Methods We implemented a newly developed 3D vascular reconstruction algorithm for clinical stroke CTA images. Based on the patient-specific vascular structure, SAFE calculates time-resolved blood flow information for the entire Circle of Willis and allows quantitative flow study of IS cases. Clinical IS cases are presented to demonstrate the feasibility. Four patients with CTA images and CT perfusion data were studied. To validate the SAFE analysis, correlation analysis comparing blood flow at the MCA, ICA, and BA was performed. Results Different blood flow patterns were found in individual IS patients. Altered flow patterns and high collateral flow rates were found near occlusions in all cases. Quantitative comparison of blood flow data showed that SAFE obtained flow data and CTP were significantly correl...Continue Reading

References

May 1, 1992·Stroke; a Journal of Cerebral Circulation·R von Kummer, W Hacke
Jun 15, 2005·Journal of Biomechanics·S MooreJ Fink
Oct 22, 2008·Medical & Biological Engineering & Computing·Aichi ChienFernando Viñuela
Feb 19, 2013·Journal of Neurointerventional Surgery·Jordan PattiAichi Chien
Jan 29, 2014·International Journal for Numerical Methods in Biomedical Engineering·Fernando MutJuan R Cebral
Nov 26, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Hyo Suk NamDavid S Liebeskind
Oct 21, 2016·Neuroradiology·Tom van SeetersUNKNOWN Dutch acute stroke study (DUST) investigators

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Citations

Apr 1, 2018·Journal of Biophotonics·Anton A NamykinIvan V Fedosov
Apr 17, 2019·Experimental and Therapeutic Medicine·Fu-Bo ZhangXin Cui

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Methods Mentioned

BETA
PCA

Software Mentioned

SPSS Statistics
SAFE

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