Analyzing functional, structural, and anatomical correlation of hemispheric language lateralization in healthy subjects using functional MRI, diffusion tensor imaging, and voxel-based morphometry

Neurology India
Jija S JamesChandrasekharan Kesavadas

Abstract

To evaluate the efficacy of diffusion fiber tractography (DFT) and voxel-based morphometry (VBM) for lateralizing language in comparison with functional magnetic resonance imaging (fMRI) to noninvasively assess hemispheric language lateralization in normal healthy volunteers. The aim of the present study is to evaluate the concordance of language lateralization obtained by diffusion tensor imaging (DTI) and VBM to fMRI, and thus to see whether there exists an anatomical correlate for language lateralization result obtained using fMRI. This is an advanced neuroimaging study conducted in normal healthy volunteers. Fifty-seven normal healthy subjects (39 males and 18 females; age range: 15-40 years) underwent language fMRI and 30 underwent direction DTI. fMRI language laterality index (LI), fiber tract asymmetry index (AI), and tract-based statistics of dorsal and ventral language pathways were calculated. The combined results were correlated with VBM-based volumetry of Heschl's gyrus (HG), planum temporale (PT), and insula for lateralization of language function. A linear regression analysis was done to study the correlation between fMRI, DTI, and VBM measurements. A good agreement was found between language fMRI LI and fiber tra...Continue Reading

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Citations

Jan 16, 2016·Der Radiologe·E R Gizewski
Dec 27, 2015·Hearing Research·Giulia PreteLuca Tommasi
Sep 20, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Mark NowellJohn S Duncan
Apr 22, 2017·AJNR. American Journal of Neuroradiology·K A SmithaC Kesavadas
Aug 12, 2017·Frontiers in Human Neuroscience·Lara SchlaffkeTobias Schmidt-Wilcke
Oct 24, 2018·Scientific Reports·Giulia PreteLuca Tommasi
Apr 3, 2020·Physiological Reviews·Onur GüntürkünSebastian Ocklenburg
Mar 12, 2020·Brain Structure & Function·Antonino Vallesi, Laura Babcock

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