Analyzing k (2 x 2) tables under cluster sampling

Biometrics
M D Begg

Abstract

In many data analytic applications, such as ophthalmologic, longitudinal, or periodontal studies, multiple observations are recorded over several sites (or timepoints) within the same subject, bringing about dependence between measurements. This correlation, in turn, precludes the use of standard statistical methods that assume independence between outcome measurements. For example, the Mantel-Haenszel statistic, used to assess association between a binary outcome and a binary exposure while adjusting for a categorical covariate, does not follow the usual chi-squared distribution under the null hypothesis when there is correlation between observations. A modified Mantel-Haenszel procedure, which makes adjustment for dependence, is proposed. No particular correlation structure is assumed for responses within a cluster. This closed-form adjustment stems from Liang and Zeger's (1986, Biometrika 73, 13-22) generalized estimating equations approach for clustered data. The difference between this tabular (i.e., noniterative) technique and many earlier tabular methods is that the current method allows for consideration of site-specific exposure and covariate information. An example from a periodontal research study illustrates applica...Continue Reading

References

Jul 1, 1987·Journal of Periodontology·J L FleissN W Chilton
Mar 1, 1996·Journal of the American Statistical Association·N E Breslow

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Citations

Jul 21, 2001·The New England Journal of Medicine·P B BachC B Begg
May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·J B DinosoF Maldarelli
Jan 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Margaret LarteyAwewura Kwara
Jul 22, 2006·Community Dentistry and Oral Epidemiology·Hae-Young KimJayasanker V Valiyaparambil
Jan 21, 2010·Journal of Clinical Laboratory Analysis·Ratana LawungVirapong Prachayasittikul
Jul 4, 2012·Acta Microbiologica Et Immunologica Hungarica·Ratana LawungVirapong Prachayasittikul
Jun 23, 1999·Statistics in Medicine·M D Begg, K S Panageas
Jun 25, 2003·Journal of Dental Research·K S PanageasI B Lamster
May 4, 2011·British Journal of Hospital Medicine·Guru Karnati, Joanna Kasznia-Brown

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