Analyzing Medical Research Results Based on Synthetic Data and Their Relation to Real Data Results: Systematic Comparison From Five Observational Studies

JMIR Medical Informatics
Anat Reiner BenaimRafael Beyar

Abstract

Privacy restrictions limit access to protected patient-derived health information for research purposes. Consequently, data anonymization is required to allow researchers data access for initial analysis before granting institutional review board approval. A system installed and activated at our institution enables synthetic data generation that mimics data from real electronic medical records, wherein only fictitious patients are listed. This paper aimed to validate the results obtained when analyzing synthetic structured data for medical research. A comprehensive validation process concerning meaningful clinical questions and various types of data was conducted to assess the accuracy and precision of statistical estimates derived from synthetic patient data. A cross-hospital project was conducted to validate results obtained from synthetic data produced for five contemporary studies on various topics. For each study, results derived from synthetic data were compared with those based on real data. In addition, repeatedly generated synthetic datasets were used to estimate the bias and stability of results obtained from synthetic data. This study demonstrated that results derived from synthetic data were predictive of results fr...Continue Reading

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Citations

Dec 31, 2020·Sensors·Ioannis VourganasLina Stankovic
Dec 29, 2020·Journal of the American Medical Informatics Association : JAMIA·Dhamanpreet KaurNatasha Markuzon
Mar 3, 2021·Internal and Emergency Medicine·Alexander KorytnyDanny Epstein
Apr 18, 2021·BMJ Open·Zahra AziziUNKNOWN GOING-FWD Collaborators
Dec 21, 2020·British Journal of Anaesthesia·Danny EpsteinAsaf Miller
Jul 3, 2021·Healthcare·Tania PereiraHélder P Oliveira
Sep 3, 2021·Scientific Reports·Rafael Y BrzezinskiOshrit Hoffer

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

Synthea
Prometheus
OSIM
medGAN
MDClone
Observational Medical Dataset Simulator ( OSIM )

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