Analyzing the acquisition of drug self-administration using growth curve models

Drug and Alcohol Dependence
Stephanie T LanzaRobert L Balster

Abstract

Current approaches to studying acquisition of drug self-administration have modest power to detect individual differences in the pattern of acquisition or to efficiently and accurately describe trajectories of behavior change. Methodological advances in human research have elucidated approaches to describing repeated measure data that focus on modeling the behavior of individual subjects. In this article, we re-analyzed data published in using growth curve modeling to characterize the acquisition of nicotine-taking in rats. Change over time in the infusion rate was examined, revealing that the acquisition process could be described with a quadratic equation represented by intercept, slope, and acceleration parameters. Unit dose of nicotine, sex and fixed ratio (FR) schedule of reinforcement had significant effects on the acquisition curves. Dose altered the absolute rate of infusions, but not the slope or acceleration, indicating that, when an effective dose was available, the shape of acquisition trajectories was not affected by dose. In addition, dose impacted acquisition by moderating the disruption in infusion rates after an increase in the response requirement. Thus, the role of a higher dose may not be to accelerate the a...Continue Reading

Citations

Aug 10, 2006·Psychopharmacology·Shannon G MattaJeffrey M Zirger
Sep 6, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Eric C DonnyAlan F Sved
Oct 27, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dorothy K HatsukamiMitch Zeller
Sep 12, 2009·Psychoneuroendocrinology·Liana FattoreWalter Fratta
Apr 29, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Oscar V Torres, Laura E O'Dell
Jun 15, 2007·Pharmacology, Biochemistry, and Behavior·W C GriffinL D Middaugh
Jul 15, 2004·Annals of the New York Academy of Sciences·Richard R Clayton
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Jan 17, 2012·Drug and Alcohol Dependence·Natalie A PeartreeJanet L Neisewander
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Jul 21, 2020·Journal of Psychopharmacology·Javier Íbias, Arbi Nazarian

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