Analyzing the relationship between decorrelation time and tissue thickness in acute rat brain slices using multispeckle diffusing wave spectroscopy

Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Joshua BrakeChanghuei Yang

Abstract

Novel techniques in the field of wavefront shaping have enabled light to be focused deep inside or through scattering media such as biological tissue. However, most of these demonstrations have been limited to thin, static samples since these techniques are very sensitive to changes in the arrangement of the scatterers within. As the samples of interest get thicker, the influence of the dynamic nature of the sample becomes even more pronounced and the window of time in which the wavefront solutions remain valid shrinks further. In this paper, we examine the time scales upon which this decorrelation happens in acute rat brain slices via multispeckle diffusing wave spectroscopy and investigate the relationship between this decorrelation time and the thickness of the sample using diffusing wave spectroscopy theory and Monte Carlo photon transport simulation.

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Citations

Mar 1, 2017·Optics Express·Michelle CuaChanghuei Yang
Sep 15, 2016·Journal of Biomedical Optics·Ashton S HemphillLihong V Wang
Nov 13, 2019·Scientific Reports·Hee-Jae JeonEuiheon Chung
Dec 1, 2017·Biomedical Optics Express·Muhammad Mohsin QureshiEuiheon Chung
Dec 29, 2020·Advances in Colloid and Interface Science·Valentina LorussoLuigi Cristofolini

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