Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor

Biological & Pharmaceutical Bulletin
T KimuraI Yamamoto

Abstract

Interactions of anandamide (N-arachidonylethanolamide), an endogenous compound for cannabinoid receptors, with the receptors for 5-hydroxytryptamine (5-HT), benzodiazepine, and gamma-aminobutyric acid(A) (GABA[A]) receptors in bovine synaptic membrane were examined. Anandamide decreased the 5-HT receptor bindings at concentrations of 1-100 microM, although it did not cause any change in benzodiazepine or GABA(A) receptor bindings. A high concentration of anandamide, 100 microM, significantly decrease both [3H]5-HT and [3H]ketanserin bindings. The present study revealed that the pharmacological activity of anandamide might be partially mediated through the 5-HT receptor.

Citations

Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·S A MooreC C Felder
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·D L BogerB F Cravatt
Oct 26, 2013·European Journal of Pharmacology·Linda A Parker
Dec 31, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Onintza SagredoRosario de Miguel
Oct 21, 2000·European Journal of Pharmacology·V Di MarzoB R Martin
Nov 16, 2007·European Journal of Clinical Pharmacology·Cristiana RossiPaola Sarchielli
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Jano J JanoyanNissar A Darmani
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Claire M Williams, Tim C Kirkham
Apr 1, 2010·Experimental Neurology·Rosaria GrecoCristina Tassorelli
Dec 23, 2009·Pharmacology, Biochemistry, and Behavior·A J TallettR J Rodgers
Mar 17, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Luciano De Petrocellis, Vincenzo Di Marzo
Sep 9, 2008·European Journal of Pharmacology·Ildikó RáczAndreas Zimmer
Sep 19, 2007·British Journal of Pharmacology·S P H Alexander, D A Kendall
Feb 6, 2014·The European Journal of Neuroscience·João Sousa-ValenteIstvan Nagy
Aug 16, 2005·Prostaglandins & Other Lipid Mediators·Mario van der Stelt, Vincenzo Di Marzo
Oct 23, 2004·Biochemical Pharmacology·Alfred A LanzafameArthur Christopoulos
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Yosefa AvrahamElliot M Berry
Sep 8, 2005·Respiratory Physiology & Neurobiology·Beata Kopczyńska, Małgorzata Szereda-Przestaszewska
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Vincenzo Di MarzoT Bisogno
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T SugiuraK Waku
Sep 5, 2006·Autonomic Neuroscience : Basic & Clinical·Linda A Parker, Cheryl L Limebeer
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paola SarchielliPaolo Calabresi
Feb 5, 2015·The Journal of Pharmacology and Experimental Therapeutics·Emma T van der WesthuizenArthur Christopoulos
Dec 24, 2010·British Journal of Pharmacology·Linda A ParkerCheryl L Limebeer
May 30, 2002·Progress in Neurobiology·Mark J Millan

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