Anandamide and decidual remodelling: COX-2 oxidative metabolism as a key regulator

Biochimica Et Biophysica Acta
Marta AlmadaN A Teixeira

Abstract

Recently, endocannabinoids have emerged as signalling mediators in reproduction. It is widely accepted that anandamide (AEA) levels must be tightly regulated, and that a disturbance in AEA levels may impact decidual stability and regression. We have previously characterized the endocannabinoid machinery in rat decidual tissue and reported the pro-apoptotic action of AEA on rat decidual cells. Cyclooxygenase-2 (COX-2) is an inducible enzyme that plays a crucial role in early pregnancy, and is also a key modulator in the crosstalk between endocannabinoids and prostaglandins. On the other hand, AEA-oxidative metabolism by COX-2 is not merely a mean to inactivate its action, but it yields the formation of a new class of mediators, named prostaglandin-ethanolamides, or prostamides. In this study we found that AEA-induced apoptosis in decidual cells involves COX-2 metabolic pathway. AEA induced COX-2 expression through p38 MAPK, resulting in the formation of prostamide E2 (PME2). Our findings also suggest that AEA-induced effect is associated with NF-kB activation. Finally, we describe the involvement of PME2 in the induction of the intrinsic apoptotic pathway in rat decidual cells. Altogether, our findings highlight the role of COX-...Continue Reading

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Citations

May 12, 2015·Molecular and Cellular Endocrinology·B M FonsecaN A Teixeira
Nov 1, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Fernando CorreaAna María Franchi
Jan 29, 2017·Journal of Molecular Cell Biology·Christopher Lipina, Harinder S Hundal
May 15, 2019·Antioxidants·Lucia Marcocci, Yuichiro J Suzuki
Feb 22, 2017·Apoptosis : an International Journal on Programmed Cell Death·M AlmadaN Teixeira
Aug 29, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·M AlmadaB M Fonseca
Jul 6, 2021·Frontiers in Endocrinology·Melissa L KozakiewiczAllyn C Howlett

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