PMID: 8594893Dec 1, 1995Paper

Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin

The American Journal of Physiology
E F EllisK A Willoughby

Abstract

Anandamide (AN, arachidonyl ethanolamide) has been isolated from the brain and shown to be an endogenous ligand for the delta 9-tetrahydrocannabinol (delta 9-THC) receptor. The purpose of these studies was to determine whether AN or delta 9-THC can affect the cerebral circulation. With the use of the closed cranial window AN and delta 9-THC (10(-13)-10(-3) M) were topically applied to rabbit cerebral arterioles and effects on diameter were measured with a microscope. AN and delta 9-THC similarly induced a dose-dependent dilation starting at concentrations as low as 10(-12) M. Maximum dilation for AN was 25% and that for delta 9-THC 22%. Topical coapplication of indomethacin, a cyclooxygenase inhibitor, completely blocked dilation, whereas the free radical scavengers superoxide dismutase and catalase or the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) had no effect on AN-induced dilation. The cerebrospinal fluid level of prostaglandin E2 increased only in response to 10(-7) M and greater AN and was not affected by delta 9-THC. [3H]AN superfused through the cranial window was 20% converted to arachidonic acid. These results show that AN and delta 9-THC can modulate cerebral arterioles, likely by stimu...Continue Reading

Citations

Feb 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David J RademacherCecilia J Hillard
Dec 18, 2013·British Journal of Pharmacology·Christopher Stanley, Saoirse E O'Sullivan
Jun 8, 2012·British Journal of Clinical Pharmacology·Christopher P StanleySaoirse E O'Sullivan
Jan 11, 2020·Frontiers in Pharmacology·Sabrina Rahman Archie, Luca Cucullo
Jan 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ying-Ying YangShou-Dong Lee
Jan 31, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Zoltán BenyóPál Pacher

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