Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease

Therapeutic Advances in Cardiovascular Disease
Virna Margarita Martín GiménezWalter Manucha

Abstract

Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.

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Citations

Jul 18, 2020·Journal of Dietary Supplements·Elnaz Karimian AzariAnnalouise O'Connor
Apr 24, 2020·Cannabis and Cannabinoid Research·Carlos Hernández-DíazMaría Cristina Paredes-Carbajal
Jan 4, 2021·Advances in Medical Sciences·Virna Margarita Martín GiménezWalter Manucha
Oct 23, 2020·Current Hypertension Reports·Carmen NavarreteEduardo Muñoz
Aug 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marilisa Pia DimmitoAdriano Mollica

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