Anaphase B precedes anaphase A in the mouse egg.

Current Biology : CB
Greg Fitzharris

Abstract

Segregation of chromosomes at the time of cell division is achieved by the microtubules and associated molecules of the spindle. Chromosomes attach to kinetochore microtubules (kMTs), which extend from the spindle pole region to kinetochores assembled upon centromeric DNA. In most animal cells studied, chromosome segregation occurs as a result of kMT shortening, which causes chromosomes to move toward the spindle poles (anaphase A). Anaphase A is typically followed by a spindle elongation that further separates the chromosomes (anaphase B). The experiments presented here provide the first detailed analysis of anaphase in a live vertebrate oocyte and show that chromosome segregation is initially driven by a significant spindle elongation (anaphase B), which is followed by a shortening of kMTs to fully segregate the chromosomes (anaphase A). Loss of tension across kMTs at anaphase onset produces a force imbalance, allowing the bipolar motor kinesin-5 to drive early anaphase B spindle elongation and chromosome segregation. Early anaphase B spindle elongation determines the extent of chromosome segregation and the size of the resulting cells. The vertebrate egg therefore employs a novel mode of anaphase wherein spindle elongation c...Continue Reading

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Citations

Oct 9, 2013·The Journal of Cell Biology·Haifeng WangJonathan M Scholey
Aug 25, 2012·Molecular Biology of the Cell·Janet E HoltKeith T Jones
Jan 6, 2016·Proceedings of the National Academy of Sciences of the United States of America·Cayetana Vázquez-DiezGreg FitzHarris
Apr 7, 2012·Trends in Cell Biology·Julien Dumont, Arshad Desai
Jun 26, 2012·Cytoskeleton·X Johné Liu
Feb 21, 2014·Cell Cycle·Maria ShomperGreg FitzHarris
Mar 10, 2012·Current Biology : CB·Keith T Jones
Dec 13, 2016·Biology·Jonathan M ScholeyIngrid Brust-Mascher
Aug 24, 2013·Biology of Reproduction·Katie Howe, Greg FitzHarris
Feb 6, 2018·Cellular and Molecular Life Sciences : CMLS·Sudhir Kumar SinghLarisa Gheber
Oct 13, 2017·Biology of Reproduction·Hugh J Clarke
Jul 22, 2018·Annual Review of Cell and Developmental Biology·Binyam MogessieMelina Schuh
May 9, 2019·Molecular Biology of the Cell·Carissa M Heath, Sarah M Wignall
Apr 28, 2017·Human Reproduction·Jenna HaverfieldGreg FitzHarris
Sep 19, 2019·Journal of Cell Science·Kruno VukušićIva M Tolić
Oct 28, 2019·Nature Communications·Lia Mara Gomes Paim, Greg FitzHarris
Nov 24, 2016·The Journal of Cell Biology·Isma BennabiMarie-Hélène Verlhac
Apr 15, 2021·Seminars in Cell & Developmental Biology·Kruno Vukušić, Iva M Tolić
Jul 3, 2021·International Journal of Molecular Sciences·Himanshu PandeyLarisa Gheber

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