Anaphylactic histamine release from peritoneal mast cells of two inbred strains of rats sensitized with mouse IgE

Agents and Actions
J WyczótkowskaC Maśliński

Abstract

Peritoneal mast cells from rats of BH- and DA-inbred strains were compared for their capacity to passive sensitization in vitro with mouse IgE antibodies. In identical experimental conditions mast cells of BH-rats were good receptors for mouse IgE anti-KLH fraction and released histamine when challenged with specific antigen, whereas mast cells of DA-rats were much less sensitized and released little histamine on the challenge. In contrast, mast cells of DA-rats wee more susceptible to the challenge with anti-rat IgE and Concanavalin A, than were cells of BH-rats. This susceptibility correlated with total serum IgE level, which was higher in DA- than in BH-rats. These results show higher concentrations of IgE on mast cells of DA--rats. It is suggested that rat IgE present on normal mast cells may be one of the factors interfering in in vitro sensitization of the cells from DA-rats with mouse IgE antibodies.

References

Jun 1, 1976·Acta Allergologica·J Wyczólkowska, C Maśliński
Jan 1, 1977·Journal of Immunological Methods·R PauwelsM van der Straeten
Jan 1, 1976·International Archives of Allergy and Applied Immunology·J Wyczolkowska, A Prouvost-Danon
Nov 1, 1972·The Journal of Clinical Investigation·E Gillespie, L M Lichtenstein

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Citations

Apr 1, 1984·Agents and Actions·E Brzezińska-BłaszczykJ Wyczółkowska

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.