Abstract
A young woman developed an anaphylactic-type reaction during induction of anaesthesia, which was later shown to be due to suxamethonium, to which the patient had not been previously exposed. In vitro testing identified not only suxamethonium as the causative agent, but also other potentially hazardous agents, pharmacologically and chemically related to suxamethonium. Furthermore, 'unrelated' neuromuscular blocking drugs elicited no reaction from the patient's leucocytes, suggesting that in future anaesthesia these agents may be used with little risk. The leucocytes of the patient's parents and brother were also tested, the brother showing a minimal positive reaction. Skin testing confirmed the significance of the in vitro histamine release by the patient's leucocytes.
References
Mar 1, 1979·Annals of Clinical Biochemistry·E SilkM Whittaker
Jun 1, 1978·British Journal of Anaesthesia·D Royston, R G Wilkes
Jan 1, 1973·International Archives of Allergy and Applied Immunology·E S Assem
Jan 1, 1967·British Journal of Anaesthesia·G JerumsP Wilson
Jul 1, 1955·Canadian Journal of Biochemistry and Physiology·W KALOW, H A LINDSAY
Jul 1, 1962·Annals of Human Genetics·H HARRIS, M WHITTAKER
Aug 1, 1963·Annals of Human Genetics·H HARRIS, M WHITTAKER
Citations
Apr 1, 1984·Agents and Actions·E S Assem
May 1, 1991·Agents and Actions·E S Assem
Apr 1, 1989·Agents and Actions·E S Assem
May 1, 1986·Canadian Anaesthetists' Society Journal·G C Moudgil
Apr 28, 1984·Lancet·D G HarleM M Fisher
Dec 1, 1990·Anaesthesia·E S Assem
Sep 1, 1983·The British Journal of Radiology·E S AssemP Dawson
Jan 1, 1989·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J A Roelofse, J J Joubert
Nov 1, 1985·British Journal of Obstetrics and Gynaecology·H S SmithE S Assem
Jan 1, 1982·Annales Françaises D'anesthèsie Et De Rèanimation·M C LaxenaireS Boileau
Nov 1, 1985·Clinical Allergy·D Vervloet
Sep 1, 1987·Clinical Allergy·A DidierD Vervloet
Feb 1, 1987·Anaesthesia·J M PuseyE S Assem
Aug 1, 1988·Anaesthesia·S M Charlton
Jun 1, 1989·Anaesthesia·M M Fisher
Feb 1, 1989·Anaesthesia·E S Assem, I E Symons
Mar 1, 1984·Anaesthesia·M M Fisher, D J Roffe
Nov 1, 1988·Anaesthesia·E S Assem, Y B Ling
May 1, 1982·Anaesthesia and Intensive Care·M M Fisher, M C Chan