Anaphylactic reactions following infusion of factor VIII in a patient with classic hemophilia

The American Journal of Medicine
R E HelmerJ A Grant

Abstract

A 28 year old white man with hemophilia A had, for several years, been successfully maintained on a home care program utilizing self-administration of factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient's basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. A subsequent life-threatening hemorrhage required cautious infusion of another commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic drugs and attempted desensitization, a moderately severe anaphylactic reaction was observed.

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Citations

Jan 1, 1995·Genetica·E Papadopulos-EleopulosD Causer
Jun 3, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·G F RivoltaA Tagliaferri
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Mar 21, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·William Beauregard Mitchell
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Jan 1, 1984·Scandinavian Journal of Haematology. Supplementum·J P Allain
Oct 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Ana Dioun BroylesMariana Castells

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