PMID: 6170242Oct 1, 1981Paper

Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma

The American Review of Respiratory Disease
E S SchulmanN F Adkinson

Abstract

Antigen challenge of passively sensitized chopped human lung resulted in the generation of several arachidonic acid cyclooxygenase metabolites (AACM): thromboxane A2 (TxA2) as measured by its stable metabolite TxB2, prostaglandin D2 (PgD2), prostacyclin (PgI2) as measured by its stable metabolite 6-keto-PgF1 alpha, prostaglandin F2 alpha (PgF2 alpha), and prostaglandin E (PgE). The kinetics of AACM release after antigen challenge paralleled histamine release. All AACM were released in an antigen dose-dependent manner and reached maximal release at antigen concentrations lower than those required for maximal histamine release. Quantitatively, of the AACM measured, PgD2 and PgI2 were found to predominate in anaphylactic reactions of human lung parenchyma. Generation of PgD2 and PgI2 were 3- to 7-fold greater than that of other AACM measured. Thromboxane B2 was generated in quantities comparable to PgE and PgF2 alpha. Studies were designed to test the hypothesis that lung smooth muscle contraction per se can account for the generated AACM that are released during anaphylaxis of the lung. The studies compared antigen-induced AACM generation with methacholine-induced (10(-4) M) AACM generation. The failure to confirm this hypothesis...Continue Reading

Citations

May 31, 2019·Animals : an Open Access Journal From MDPI·Luisauris JaimesJosé L Martínez
Apr 2, 2019·Experimental Lung Research·Tamami SakaiShinji Nakao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Related Papers

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
E S SchulmanH H Newball
The Journal of Allergy and Clinical Immunology
T AhmedW Abraham
© 2021 Meta ULC. All rights reserved