Jun 11, 1998

Anaphylactic shock associated with a central venous catheter impregnated with chlorhexidine and silver sulfadiazine

Masui. The Japanese journal of anesthesiology
E TerazawaS Dohi

Abstract

A 28 year-old male patient developed anaphylactic shock on separate occasions, possibly due to the contact with a central venous catheter impregnated with chlorhexidine and silver sulfadiazine. He was successfully resuscitated. On the second operation, blood basophils disappeared and plasma histamine level increased extremely up to 80 ng.ml-1 soon after anaphylactic shock. One year after the first shock, he did not develop anaphylactic shock following the insertion of a central venous catheter without the impregnation. Pin prick test and scratch test showed positive reactions only to chlorhexidine. Latex-specific anti-IgE antibody was not detected. Therefore, chlorhexidine was confirmed as the causative agent of anaphylactic shock. Because chlorhexidine is extensively used as an antiseptic drug in emergency rooms and intensive care units, we should be aware of the possibility of chlorhexidine induced anaphylactic reactions.

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Mentioned in this Paper

Dermazin
Spastic Paraplegia 17
Anaphylaxis
Microbicides, Topical
Catheterization, Central Venous
Tubulicid

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.