Sep 1, 1994

Anaphylactic shock by ophthalmic wash solution containing chlorhexidine

Masui. The Japanese journal of anesthesiology
T OkudaY Koga


A 58 year-old male patient developed anaphylactic shock, possibly due to the use of chlorhexidine as ophthalmic wash solution. He was successfully resuscitated without any sequelae. The patient had increased levels of both histamine and tryptase. The skin test for allergy resulted in strong positive to chlorhexidine. There have been many reports regarding severe adverse reactions associated with use of chlorhexidine. It is necessary to pay attention to anaphylactic shock due to chlorhexidine.

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Mentioned in this Paper

Histamine Measurement
Tryptase Measurement
Allergy Testing
Injuries, Surgical
General Anesthesia
Allergy Testing Histamine (Lab Test)
Retinal Pigment Epithelial Detachment

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.