Anaphylactic shock due to intravesical administration of pirarubicin hydrochloride for the fifth time

Journal of Clinical Anesthesia
Koji SakataHiroki Iida

Abstract

We report the first case of anaphylaxis induced by intravesical administration of pirarubicin hydrochloride during spinal anesthesia. The patient was a 64-year-old woman being followed up for transitional cell carcinoma of the bladder. Anaphylaxis occurred the fifth time pirarubicin hydrochloride was administered intravesically. Pirarubicin hydrochloride, an anthracycline antitumor antibiotic that is widely used for intravesical instillation chemotherapy, is administered at the end of surgery. Because this is about the time that the patient is leaving the operating room, attention to patient monitoring tends to be divided. Because anaphylaxis may occur at this time, staff should remain vigilant of the risk of anaphylaxis.

References

May 24, 2000·Journal of Clinical Pathology·R S Pumphrey, I S Roberts
Sep 22, 2006·Acta Anaesthesiologica Scandinavica·L ColapaoliA B Guttormsen
May 7, 2008·Current Opinion in Anaesthesiology·Pascale Dewachter, Claudie Mouton-Faivre

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.