PMID: 6609269Dec 1, 1983

Anaphylatoxin formation during hemodialysis: effects of different dialyzer membranes

Kidney International
D E ChenowethL W Henderson

Abstract

Measurable complement activation resulting in the formation of both C3a and C5a anaphylatoxins was observed in 12 patients undergoing maintenance dialysis treatment with cuprophan hollow fiber dialyzers. Specific radioimmunoassay measurements demonstrated that these patients displayed significantly elevated levels of C3a antigen in the venous (outflow) line of the dialyzer after only 2 min of dialysis. During hemodialysis, venous plasma C3a levels continued to increase and became maximally elevated after 15 min. Thereafter, C3a concentrations gradually declined, suggesting that the rate of complement activation abates with continued cuprophan hemodialysis. Complement activation, as judged by venous plasma C3a levels, was also temporally correlated with hemodialysis leukopenia. The factor believed to be responsible for pulmonary vascular leukosequestration, C5a, could also be detected in venous plasma, but levels of this antigen were not strikingly elevated until the later stages of dialysis. By contrast, six patients dialyzed with polyacrylonitrile dialyzers failed to exhibit hemodialysis leukopenia and displayed only very modest increases in their plasma C3a levels during the initial phases of hemodialysis. These observations ...Continue Reading

References

Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Mar 25, 1968·JAMA : the Journal of the American Medical Association·L S Kaplow, J A Goffinet
Jul 9, 1981·The New England Journal of Medicine·M J DolanK Wasserman
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S K LawR P Levine
Jul 1, 1982·The Journal of Experimental Medicine·D E ChenowethW O Weigle
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie
Oct 23, 1980·The New England Journal of Medicine·A S Relman

Citations

Apr 1, 1993·Journal of Biomedical Materials Research·S ParzerC Mannhalter
Jun 1, 1988·Inflammation·H R LamcheD E Hammerschmidt
Jan 1, 1992·Biomaterials·A Remes, D F Williams
Mar 1, 1995·Journal of Critical Care·J L Vincent, C Tielemans
Feb 25, 1998·Transplantation Proceedings·H SetoyamaY Ikada
Feb 26, 2000·Acta Physiologica Scandinavica·M NishimuraM Yoshimura
Oct 4, 1984·The New England Journal of Medicine·R HakimF K Port
Oct 4, 1984·The New England Journal of Medicine·G Eknoyan
Feb 14, 1985·The New England Journal of Medicine·J E VolanakisJ H Galla
May 16, 1985·The New England Journal of Medicine
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Apr 1, 1986·Artificial Organs·S Murabayashi, Y Nosé
Apr 1, 1987·Artificial Organs·D E Chenoweth, L W Henderson
Jun 1, 1987·Artificial Organs·J Vienken, U Baurmeister
Dec 1, 1988·Artificial Organs·D E Chenoweth
Feb 1, 1989·Artificial Organs·U BaurmeisterA Luttrell
Apr 1, 1989·Artificial Organs·M Haag-WeberW H Hörl
Feb 1, 1994·Journal of Clinical Pathology·A InnesR J Powell
Jan 1, 1991·Journal of Biomaterials Science. Polymer Edition·A M Françoise GachonP Deteix
Jan 1, 1993·Journal of Biomaterials Science. Polymer Edition·R M Cornelius, J L Brash
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·N MorikawaY Ikada
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·J R FrautschiJ A Gelfand
Apr 1, 1986·The Journal of Clinical Investigation·P W SandersJ H Galla
Feb 1, 1986·Archives of Toxicology·J H RommesA N van Heijst
Jan 1, 1991·Platelets·M P Gordge, G H Neild
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·A P Dalmasso
Nov 16, 2010·International Reviews of Immunology·Carmelo LibettaA Dal Canton
Jan 1, 1989·Scandinavian Journal of Urology and Nephrology·L G WeissB Wikström
Dec 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·F KnudsenC Jersild
Jan 1, 1988·Biomaterials, Artificial Cells, and Artificial Organs·D E Hammerschmidt, G M Vercellotti
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jonathan HimmelfarbE McMonagle
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M Lazarus, W F Owen
Aug 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B J PereiraC A Dinarello
May 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S L Lewis, D E Van Epps
Apr 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M CardosoL Lapierre
May 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T B WiegmannD A Diederich
Nov 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M CampistolL Revert
Aug 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N H ShustermanB L Strom
Oct 29, 2013·Seminars in Nephrology·James W McCulloughJoshua M Thurman
Dec 1, 1990·Kidney International·M Laude-SharpN Haeffner-Cavaillon
Feb 1, 1989·Kidney International·A K CheungJ Janatova
Sep 1, 1993·Kidney International·R Hakim
Sep 1, 1992·Kidney International·M BrockhausN Haran
Dec 1, 1987·Kidney International·Q MaggioreA Mundo
May 1, 1987·Kidney International·A K CheungA L Wayman
Jul 1, 1986·Kidney International·A K CheungL W Henderson
Jan 1, 1987·Kidney International·S L LewisD E Chenoweth
Apr 1, 1986·Kidney International·A K CheungL W Henderson
Apr 1, 1986·Kidney International·L W Henderson
May 1, 1989·Kidney International·N Haeffner-CavaillonM D Kazatchkine
Jan 1, 1988·Kidney International·G LonnemannC A Dinarello
Mar 1, 1993·Kidney International·R SchindlerK M Koch
Apr 1, 1993·Kidney International·M Pascual, J A Schifferli
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson
Jan 1, 1990·Kidney International·R SchindlerC A Dinarello
Apr 1, 1995·Kidney International·S M Baumgartner-ParzerC Mannhalter
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A MungerE H Marshall
Mar 29, 2003·Artificial Organs·Richard A Ward, Kenneth R McLeish
Apr 1, 1990·Journal of Cardiothoracic Anesthesia·F Knudsen, L W Andersen
Jul 21, 2000·Scandinavian Journal of Urology and Nephrology·Y YeniçeriogluE S Uçan
Mar 7, 2002·Artificial Organs·Joerg Vienken, Sudhir Bowry
Feb 28, 2017·Nature Reviews. Nephrology·Kristina N EkdahlBo Nilsson
Mar 1, 2000·The Journal of Thoracic and Cardiovascular Surgery·H GrimmL Ermert
Jan 1, 1991·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·R BambauerW K Jung
Jan 1, 1991·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·H Schiffl, T Strasser
Oct 6, 2004·Seminars in Dialysis·Allessandro Bellucci
May 1, 1991·Journal of Biomedical Materials Research·S OmokawaY Nosé
Jan 1, 1987·Annals of the New York Academy of Sciences·D E Chenoweth
Jul 27, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Ke WangHFM Study
May 16, 2020·International Journal of Molecular Sciences·Vincenzo LosappioGiovanni Stallone
Jul 16, 2002·The International Journal of Artificial Organs·V SirolliM Bonomini
Feb 1, 1990·Anaesthesia and Intensive Care·D M Dickson, K M Hillman
Feb 10, 2018·Frontiers in Immunology·Felix PoppelaarsMarc A Seelen
Apr 17, 2019·Journal of Cardiovascular Translational Research·Yaqin WangMing-Hui Zhao

Related Concepts

Cuprammonium cellulose
AN-69 Sodium
Acrylic Resins
Acrylonitrile
Anaphylatoxin
Hemocompatible Materials
Sulfite Cellulose
Complement Activation
Complement C3 precursor
Complement C4, Precursor

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.