PMID: 2478047Oct 1, 1989Paper

Anaphylaxis following administration of papaveretum. Case report: Implication of IgE antibodies that react with morphine and codeine, and identification of an allergenic determinant.

Anesthesiology
D G HarleM M Fisher

Abstract

IgE antibodies that reacted with morphine and codeine were detected in the serum of a subject who experienced a life-threatening anaphylactic reaction following the administration of Omnopon-Scopolamine (papaveretum-hyoscine). Hapten inhibition studies with morphine and a number of structurally-related analogues revealed that morphine and codeine were the most potent inhibitors of IgE binding to a morphine-solid phase. Nalorphine, meperidine, and methadone were also good inhibitors of IgE binding, but naltrexone, buprenorphine, and fentanyl proved to be poor inhibitors. From a detailed examination of structure-activity relationships, the authors conclude that the important structural features of the morphine allergenic (that is, IgE binding) determinant comprises the cyclohexenyl ring with a hydroxyl group at C-6 and, most important of all, a methyl substituent attached to the N atom. The authors' findings suggest that morphine analogues administered to such a patient may provoke clinical anaphylaxis. Hyoscine reacted weakly with IgE antibodies in the subject's serum, but this was thought to be due to weak cross-reaction between this compound and morphine.

Citations

Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·T van LaarJ A Bruijn
Jan 6, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·G Wurpts, J M Baron
Mar 1, 1995·Molecular Immunology·J L GuéantM C Laxenaire
Mar 12, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·L GuillouxE Beaudouin
Jul 9, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Bernard Yu-Hor Thong, Yeow-Chan
Feb 7, 2001·Allergy·B AníbarroF J Seoane
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·B A BaldoZ Zhao
Oct 23, 2003·Anesthesia and Analgesia·David L Hepner, Mariana C Castells
Jun 18, 2010·Anesthesia Progress·Daniel E Becker
Jan 16, 2014·Anesthesia Progress·Daniel E Becker
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S M Nasser, P W Ewan
Jul 27, 2012·International Archives of Allergy and Immunology·Kevin FarnamM Eric Gershwin
Oct 12, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Mar 17, 2010·The Journal of Allergy and Clinical Immunology·Lisa M StutiusDale T Umetsu
May 12, 2007·Immunology and Allergy Clinics of North America·Thomas Chacko, Dennis Ledford
Oct 27, 2006·Allergologia et immunopathologia·L Prieto-LastraA García-Cubero
Apr 20, 2007·Allergy·D G EboW J Stevens
Apr 7, 2004·Acta Clinica Belgica·D G EboW J Stevens
Jan 18, 2011·British Journal of Clinical Pharmacology·Linda Nel, Efrem Eren
Jul 8, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B A BaldoN H Pham
Mar 5, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S SwertsD G Ebo
Sep 1, 1991·International Journal of Obstetric Anesthesia·J E Honet, M C Norris
Jan 1, 1993·Annales Françaises D'anesthèsie Et De Rèanimation·B A Baldo, M M Fisher
Jan 1, 1993·Annales Françaises D'anesthèsie Et De Rèanimation·B A Baldo, M M Fisher
Jan 24, 2006·Contact Dermatitis·A J Hogen EschP J Coenraads
Jun 21, 2002·European Journal of Anaesthesiology·P M Mertes, M C Laxenaire
Jan 10, 2014·Allergy, Asthma & Immunology Research·Hye-Soo YooHae-Sim Park
Apr 7, 2015·Immunology and Allergy Clinics of North America·Merin Kuruvilla, David A Khan
Aug 10, 2010·The Journal of Allergy and Clinical Immunology·Phillip LiebermanDana Wallace
Oct 28, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Phillip LiebermanStephen A Tilles
Feb 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B A BaldoN H Pham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Related Papers

Clinical Pharmacology and Therapeutics
E F EvansA J Wasserman
Anesthesia Progress
Daniel E Becker
Chemical Immunology and Allergy
O HausmannW J Pichler
© 2022 Meta ULC. All rights reserved