PMID: 39417Jun 1, 1979

Anaphylaxis in the monkey: respiratory mechanics, acid-base status and blood gases

Acta Anaesthesiologica Scandinavica
B RevenäsK E Arfors

Abstract

Aggregate anaphylaxis was induced by intravenous injection of the specific antigen in eight ovalbumin-sensitized monkeys. Changes in respiratory mechanics, acid-base status and blood gases were studied during the following half hour. Within 1 minute after challenge, a short period of respiratory depression, probably reflex-mediated, was observed. This was followed by hyperventilation, and arterial PCO2 decreased. There was a rapid increase in pulmonary resistance (Rpulm) and a concomitant decrease in pulmonary dynamic compliance (Cdyn), suggesting constriction of smooth muscles in the lung. Rpulm returned to the control value but Cdyn remained depressed, as a result of constriction of small airways and pulmonary congestion. Oxygen saturation in arterial blood decreased slightly due to a marked desaturation of mixed venous blood and increased venous admixture. Progressive metabolic acidosis developed, indicating poor tissue oxygenation and perfusion. The changes observed in this study were not severe enough to cause any major disturbance of the gas exchange in the lungs, despite a severe anaphylactic shock.

References

Sep 1, 1982·Klinische Wochenschrift·J Watkins, J A Thornton
Mar 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J H GaudyJ F Boitier
Oct 1, 1979·Acta Anaesthesiologica Scandinavica·B RevenäsK E Arfors
Jun 1, 1979·Acta Physiologica Scandinavica·G SmedegårdK E Arfors
Aug 31, 1981·Biochemical and Biophysical Research Communications·S HammarströmP Hedqvist
Jul 10, 2013·Respiratory Physiology & Neurobiology·Grégoire BarthelFrançois Marchal
May 26, 2017·Experimental Lung Research·Feng ZhengOlivier Collange
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·D IluchevS Lazarov

Citations

Jun 1, 1979·Acta Physiologica Scandinavica·G SmedegårdK E Arfors
Jun 1, 1977·Acta Physiologica Scandinavica·J Vaage, A Hauge
Mar 1, 1973·British Journal of Pharmacology·P EyreP W Wells
Dec 1, 1974·Acta Physiologica Scandinavica·J VaageJ Hognestad
Feb 1, 1970·Anesthesiology·D M PhilbinE M Papper
Mar 1, 1967·Journal of Applied Physiology·P T Macklem, J Mead
Mar 1, 1969·Journal of Applied Physiology·M J NovyR E Behrman
Jan 1, 1970·Journal of Applied Physiology·E S MunsonI H Wagman
Jun 4, 1970·The New England Journal of Medicine·J Mead
Mar 31, 1929·The Journal of Experimental Medicine·E D Churchill, O Cope

Related Concepts

Tidal Volume
Dioxygen
Variolation
Anaphylaxis (Non Medication)
Lung
Depressed - Symptom
Intravenous Injections
Molecular Oxygen Saturation
Blood Gas
Smooth Muscle

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.