PMID: 8943892Dec 1, 1996Paper

Anaplastic large cell (CD30/Ki-1+) lymphoma in HIV+ patients: clinical and pathological findings in a group of ten patients

British Journal of Haematology
A NosariE Morra

Abstract

We compared the clinical and pathological features of 10 HIV+ CD30+ anaplastic large cell lymphoma (ALCL) patients with 28 HIV+ CD30- non-Hodgkin's lymphoma (NHL) patients. The incidence of ALCL among 38 HIV+ systemic NHL patients was 26%. Clinical features were similar in all the HIV-related NHL cases, but ALCL patients seemed to differ from HIV+ CD30- systemic NHL only in the greater frequency of lung tumours (40% v 21%) without concomitant mediastinal mass, bone marrow (75% v 18%) and gastroenteric involvement (40% v 25%). Among the HIV+ ALCL patients, histologic subtypes did not differ in frequency from ALCL in the general population. The B phenotype was predominant (50%) as in other HIV-related NHL. EBV genoma, studied in all HIV+ ALCL patients, was present in 3/10 by in situ hybridization (ISH) and in 5/10 cases using PCR. The clinical course of lymphomas was similar in CD30 positive and negative NHL patients. Overall survival also was short in our series, particularly in HIV+ ALCL (84 v 188 d), probably because of profound immunodepression of the ALCL patients. Our findings suggest that severe immunodepression due to HIV infection determines-more than any other factor-the clinical features of HIV+ ALCL, making them very ...Continue Reading

Citations

Mar 31, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·A P BurkeR Virmani
Jun 14, 2001·British Journal of Haematology·S W MorrisM C Kinney
May 18, 1999·The American Journal of Surgical Pathology·D A ArberL M Weiss
Aug 30, 2008·AIDS·Victor E NavaMetin Ozdemirli
May 12, 2000·Seminars in Thoracic and Cardiovascular Surgery·K Katariya, R J Thurer
Feb 10, 2010·Leukemia & Lymphoma·Kimberly PerezLiron Pantanowitz
Jul 13, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Karo K ArzooAlexandra M Levine
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·W L RushM N Koss
Feb 5, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·H KatanoS Mori
Oct 16, 1999·Hematological Oncology·G A Young

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