Anaplastic large cell lymphoma in human immunodeficiency virus-infected people and solid organ transplant recipients.

British Journal of Haematology
Parag MahaleEric A Engels

Abstract

Human immunodeficiency virus (HIV)-infected people and solid organ transplant recipients have elevated risk of anaplastic large cell lymphoma (ALCL). Little is known regarding ALCL risk factors in immunosuppressed populations. We used data from US cancer registries linked to HIV registries (1996-2016) and to the national transplant registry (1992-2017). ALCL risk in HIV-infected people and transplant recipients relative to the general population was calculated as a standardized incidence ratio (SIR). ALCL risk factors were evaluated using Poisson regression. We identified 121 incident ALCL cases in the HIV (n = 86) and transplant (n = 35) populations. We reviewed pathology reports for 45 cases and most (86·7%) were confirmed as ALCL. Epstein-Barr virus tested positive in 1/8 (12·5%) cases. Compared to the general population, ALCL risk was strongly elevated among HIV-infected people [SIR 5·43; 95% confidence interval (CI) 4·27-6·81] and transplant recipients (5·96; 4·03-8·49). Among HIV-infected people, ALCL incidence was strongly related to CD4 count [adjusted incidence rate ratio (aIRR) 0·15 for ≥500 vs. <200 cells/μl; P trend < 0·001]. Among transplant recipients, risk was highest within the first year (aIRR 6·82) and 10+ yea...Continue Reading

References

Apr 1, 1995·The American Journal of Surgical Pathology·K P MannH Ratech
Jul 1, 1996·Leukemia & Lymphoma·M ClavioM Gobbi
May 1, 1997·Southern Medical Journal·P Bozner, M Y Elkhalifa
Mar 31, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·A P BurkeR Virmani
Apr 24, 2004·The American Journal of Surgical Pathology·Sean D PitmanJun Wang
Oct 29, 2004·Nature Reviews. Cancer·Lawrence S Young, Alan B Rickinson
Sep 10, 2005·Blood·Lindsay M MortonMartha S Linet
Jan 4, 2007·The Journal of Pathology·A L GruverG D Sempowski
Aug 21, 2007·Human Pathology·Sherif A Rezk, Lawrence M Weiss
Nov 21, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J W HarbellL W Teperman
Apr 26, 2008·International Journal of Cancer. Journal International Du Cancer·Eric A EngelsJames J Goedert
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie VoseUNKNOWN International T-Cell Lymphoma Project
Aug 30, 2008·AIDS·Victor E NavaMetin Ozdemirli
Mar 26, 2009·Journal of the National Cancer Institute·Nadia HowladerBrenda K Edwards
Feb 10, 2010·Leukemia & Lymphoma·Kimberly PerezLiron Pantanowitz
Nov 3, 2011·JAMA : the Journal of the American Medical Association·Eric A EngelsMonica Lin
Sep 5, 2012·Annals of Internal Medicine·Keri N AlthoffUNKNOWN North American AIDS Cohort Collaboration on Research and Design
Jun 13, 2013·British Journal of Cancer·C A ClarkeE A Engels
Apr 2, 2015·Blood·Aaron ArveyEthel Cesarman
Jul 2, 2015·Proceedings·Michael L KrolAdan Mora
Nov 19, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Parag MahaleEric A Engels

❮ Previous
Next ❯

Citations

Nov 16, 2021·Infectious Agents and Cancer·Parag MahaleEric A Engels

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.