Anaplastic lymphoma kinase expression in small-cell lung cancer

Histopathology
Chiaki KondohYasushi Yatabe

Abstract

Anaplastic lymphoma kinase (ALK) immunohistochemistry has shifted from being a screening tool to being a sole determinant for ALK-targeted therapy. Recent articles have referred to small-cell lung cancer (SCLC) transformation as a resistance mechanism after ALK inhibitor treatments, but few reports have addressed ALK expression in treatment-naive SCLC in a comprehensive manner. Therefore, we examined ALK expression and the mechanisms in treatment-naive SCLCs. We examined ALK expression in a consecutive series of SCLC tumours, and the expression mechanism was analysed regarding gene rearrangement, copy number changes, and point mutations. We also examined whether SCLC with ALK expression can be suppressed by crizotinib treatment in vitro. Immunohistochemical results revealed that ALK was expressed in 16 of 142 (11.3%) SCLCs. The expression was focal and less intense, which is in contrast to strong and uniform expression in adenocarcinoma with ALK rearrangement. Two combined SCLCs showed a positive reaction restricted to the SCLC component. None of the known genetic alterations, including rearrangement, amplification, copy number gain, or point mutations, were associated with ALK expression. A SCLC cell line, SKLC2, which express...Continue Reading

References

May 4, 2000·The American Journal of Pathology·L LamantB Mariamé
Aug 10, 2000·The American Journal of Pathology·B LawrenceJ A Fletcher
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffery L Kutok, Jon C Aster
Apr 20, 2004·Journal of Cellular Physiology·K PulfordF Turturro
Jul 1, 2004·Journal of Cell Science·Akira MotegiTadashi Yamamoto
Jul 11, 2006·The Journal of Molecular Diagnostics : JMD·Yasushi YatabeTetsuya Mitsudomi
Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kentaro InamuraYuichi Ishikawa
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jussi P KoivunenPasi A Jänne
Oct 17, 2008·Nature·Yuyan ChenSeishi Ogawa
Feb 24, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kentaro InamuraYuichi Ishikawa
Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Larisa V DebelenkoJulia A Bridge
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marta SalidoEdurne Arriola
Mar 25, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kengo TakeuchiYuichi Ishikawa
Jan 11, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·William D Travis
Jun 2, 2012·Frontiers in Oncology·Yoshiko MurakamiYasushi Yatabe
Apr 27, 2013·Journal of Clinical Pathology·Harumi NakamuraHitoshi Tsuda
Jun 4, 2013·The New England Journal of Medicine·Alice T ShawPasi A Jänne
Oct 5, 2013·Biochemical Pharmacology·Beverly A Teicher
Feb 13, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Florian CabillicMarc-Antoine Belaud-Rotureau
Aug 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jean-Claude CutzMing-Sound Tsao
Dec 4, 2014·The New England Journal of Medicine·Benjamin J SolomonUNKNOWN PROFILE 1014 Investigators
Mar 20, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yasushi Yatabe
Jun 10, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Spasenija SavicLukas Bubendorf
Nov 26, 2015·Seminars in Diagnostic Pathology·Alberto M Marchevsky, Mark R Wick
Jan 12, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shiro FujitaYasushi Yatabe
Jan 27, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N TakegawaK Nakagawa
Feb 27, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Antonio MarchettiFiamma Buttitta
Dec 22, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Erik ThunnissenMasayuki Noguchi
Oct 28, 2017·Nature Reviews. Cancer·Adi F GazdarJohn D Minna
Apr 13, 2018·Cancers·Ricky M Trigg, Suzanne D Turner

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Citations

Jun 11, 2020·American Journal of Clinical Oncology·Gerald ClamonTaher A Hejleh
Sep 6, 2020·American Journal of Clinical Oncology·Gerald ClamonTaher A Hejleh

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