Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma arising in a patient with hypersensitivity to mosquito bites

Korean journal of family medicine
Jin Hee KangHyun Jeong Park

Abstract

Hypersensitivity to mosquito bites is defined as the appearance of intense skin reactive lesions and systemic symptoms subsequent to mosquito bites. Most cases of hypersensitivity to mosquito bites reported thus far have been associated with chronic Epstein-Barr virus infection or natural killer cell leukemia/lymphoma. In this study, we describe the case of an 18-year-old Korean boy who had hypersensitivity to mosquito bites associated with primary systemic anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. After a mosquito bite, the patient developed a progressive cutaneous nodule on his left lower leg and regional lymphadenopathy in the left inguinal area. The histopathological and immunohistochemical findings suggested anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Positron emission tomography-computed tomography revealed increased fluorodeoxyglucose uptake in the left T4 vertebrae, left external iliac lymph nodes, left inguinal lymph nodes, and lateral subcutaneous region of the left lower leg. According to the clinical, histopathological, and immunohistochemical findings, as well as the imaging data, the patient was diagnosed with primary systemic anaplastic lymphoma kinase-positive an...Continue Reading

References

Aug 6, 2004·International Journal of Hematology·Keiko AsakuraYasuo Ikeda
Mar 15, 2006·International Journal of Hematology·Takaaki KonumaShigetaka Asano
Oct 25, 2007·Blood·Marie-Cécile Le DeleyUNKNOWN European Intergroup for Childhood Non-Hodgkin Lymphoma
Jul 29, 2009·Journal of Pediatric Hematology/oncology·Zhengxiang ZhangXiaojun Zhou
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia ParkYoung Hyeh Ko

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Citations

Mar 28, 2017·Journal of Cutaneous Pathology·Ryanne A BrownJinah Kim
Jan 4, 2020·Indian Journal of Dermatology·Litao WangGuiying Zhang
Oct 9, 2021·Journal of Cutaneous Pathology·Yaping ZhangWenyan Zhang

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Methods Mentioned

BETA
biopsy

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