Anaplastic progression of classic Kaposi's sarcoma

Dermatology : International Journal for Clinical and Investigative Dermatology
D CerimeleS Cavalieri

Abstract

We describe a case of classic Kaposi's sarcoma (KS) in an Italian HIV-negative patient, with bone involvement and progression to anaplastic histotype. At the age of 22, violaceous patches of KS appeared on his feet. At the age of 50, he noted the appearance of a violaceous firm nodule on his right wrist. The lesions grew rapidly and became ulcerated. Radiotherapy led to a complete remission of symptoms. At the age of 55, a subcutaneous nodule developed on the proximal third of the right forearm associated with a wide painful edema of the right forearm and the proximal third of the right arm. The nodule enlarged rapidly, and an X-ray of the right forearm revealed the presence of a large osteolytic area of the ulna. A biopsy specimen from the right ulna showed bone erosion by a mesenchymal neoplasia with a high degree of malignancy. The right arm was amputated, and histologic examination of the surgical material confirmed the diagnosis of undifferentiated spindle-cell malignant neoplasia strongly positive for factor-VII-related antigen and CD34 antigen. Three years after surgical treatment, no recurrences have been observed.

Citations

Dec 12, 2001·The British Journal of Dermatology·R SattaF Cottoni
Jul 29, 2008·Diagnostic Pathology·Wayne Grayson, Liron Pantanowitz
Jul 22, 2008·Journal of the American Academy of Dermatology·Robert A SchwartzLaura Scuderi
Aug 31, 2004·Journal of Surgical Oncology·Robert A Schwartz
Sep 18, 2010·The British Journal of Dermatology·N MartíE Jordá
Jul 30, 2009·Journal of Cutaneous Pathology·Yue YuMeera Mahalingam
Sep 14, 2018·Advances in Anatomic Pathology·Michele BiscegliaDavid J Ben-Dor
Jan 20, 2021·The American Journal of Dermatopathology·Patricia AlvarezOmar Sangueza

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