Anaplastic sarcoma of the kidney with chromosomal abnormality: first report on cytogenetic findings

Human Pathology
Kiyoshi GomiYukichi Tanaka

Abstract

We report a case of anaplastic sarcoma of the kidney (ASK) with cytogenetic findings. A 12-year-old Japanese girl presented with buttock pain and urinary incontinence. Radiological investigations revealed a right renal tumor with multiple distant metastases and multicystic thyroid tumor. She underwent radical right nephrectomy and subsequently received chemotherapy and radiation therapy. Histologically, the renal tumor demonstrated admixture of various types of mesenchymal elements: cellular spindle cells with anaplastic features, cartilage, and rhabdomyoblastic cells consistent with ASK. Chromosomal analysis revealed the karyotype of the tumor cells to be 46, XX, +8, -10, der (18) t (10; 18) (q21; p11.2). The thyroid tumor was removed later and diagnosed as adenomatous goiter. To our knowledge, this is the first case of ASK with chromosomal abnormality and may provide new insight into the molecular biologic basis of this rare renal tumor.

References

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Citations

Mar 2, 2016·Pediatric Blood & Cancer·Mona Kay WuWilliam D Foulkes
Oct 19, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Noriko WatanabeMasahiko Sugitani
Sep 2, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mona K WuWilliam D Foulkes
Sep 21, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mikako WarrenRachana Shah
May 6, 2020·World Journal of Clinical Cases·Jsun-Liang KaoChih-Chung Shiao
Mar 24, 2016·International Journal of Surgical Pathology·Haitham ArabiHassan Huwait
Sep 14, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Lauren Kroll-Wheeler, Amer Heider

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