Anaplastic thyroid carcinoma accompanied by uncontrollable eosinophilia

Internal Medicine
Jun ShiraishiMitsuyoshi Namba

Abstract

Anaplastic thyroid carcinoma is a rare disease, and cases associated with eosinophilia are even rarer. We herein report a case of anaplastic thyroid carcinoma accompanied by remarkable and uncontrollable eosinophilia. A 71-year-old man was diagnosed with end-stage anaplastic thyroid carcinoma. Throughout the aggressive clinical course of the cancer, eosinophilia dramatically progressed and became extremely refractory to steroid treatment. We measured the serum levels of hematopoietic cytokines potentially involved in eosinophilia, including granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5. Although the GM-CSF level was moderately elevated, both the IL-3 and IL-5 levels were within the normal ranges. In this case, the patient's eosinophilia may have been related to his severe dyspnea and was likely responsible for the allergic reaction to the anticancer drug. Therefore, it is essential to elucidate the etiology of eosinophilia in patients with thyroid cancer in order to improve the treatment for patients with anaplastic thyroid carcinoma.

References

Feb 24, 2001·Thyroid : Official Journal of the American Thyroid Association·T SatoT Nishikawa
Mar 11, 2004·British Journal of Haematology·Emi Hamaguchi-TsuruAkira Tominaga
Dec 21, 2006·Hormones : International Journal of Endocrinology and Metabolism·Evangeline VassilatouIoanna Tzavara
Jan 1, 2010·BMJ Case Reports·Einstein Francisco CamargosAlexandre Cavalca Tavares
Aug 8, 2012·The Journal of Clinical Endocrinology and Metabolism·Robert C Smallridge
Oct 11, 2012·Immunological Reviews·Sophie E BroughtonMichael W Parker

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Citations

Jul 30, 2016·Oncoimmunology·Maria Rosaria GaldieroGianni Marone
Aug 16, 2019·International Journal of Molecular Sciences·Gilda VarricchiMaria Rosaria Galdiero
Apr 13, 2021·Frontiers in Oncology·Ewa ZalewskaKrzysztof Sworczak

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