PMID: 7539648Jan 1, 1995Paper

Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): report of a case

Surgery Today
K IwasaT Michigishi

Abstract

We report herein the unusual case of a 60-year-old woman with an anaplastic thyroid carcinoma which produced granulocyte colony stimulating factor (G-CSF). She presented with large neck masses, respiratory difficulty, and a high fever. Laboratory examinations revealed marked leukocytosis of 43,200/mm3 with 85% granulocytes and an elevated G-CSF level of 67 pg/dl. Total thyroidectomy with bilateral node dissection and tracheostomy was performed, and a histological diagnosis of large-cell anaplastic thyroid carcinoma was confirmed. Immunohistochemical examination with a polyclonal antibody against G-CSF stained the tumor cells. Although the respiratory difficulty, fever, and marked granulocytosis subsequently improved, she died 1 month after undergoing surgery due to metastatic mediastinal disease.

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Citations

Dec 20, 2011·Thyroid : Official Journal of the American Thyroid Association·Robert NakayamaHideo Morioka
Jan 22, 2010·Clinical Nuclear Medicine·Yuji NakamotoKaori Togashi
Jan 1, 2010·BMJ Case Reports·Einstein Francisco CamargosAlexandre Cavalca Tavares
Dec 7, 1996·Lancet·D A de Luis, E Romero
Oct 26, 2016·World Journal of Clinical Oncology·Hiroaki NagataHiroshi Konosu
Feb 15, 2018·Blood Cancer Journal·Natasha Szuber, Ayalew Tefferi
Jun 1, 2019·Cancer Cytopathology·Esther Diana RossiLiron Pantanowitz
Nov 27, 2019·American Journal of Hematology·Natasha SzuberAyalew Tefferi
Jun 27, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Shimpei SugiuraHisashi Oshiro
Jun 1, 2019·International Cancer Conference Journal·Yuzuru SakamotoAkinobu Taketomi
Nov 24, 2020·Case Reports in Endocrinology·Hiroyuki IwasakiHiroyuki Takahashi
Apr 1, 2021·Clinical Journal of Gastroenterology·Akifumi KuwanoKenta Motomura

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