Anastomotic biliary strictures after liver transplantation: causes and consequences

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Robert C VerdonkElizabeth B Haagsma

Abstract

We retrospectively studied the prevalence, presentation, results of treatment, and graft and patient survival of grafts developing an anastomotic biliary stricture (AS) in 531 adult liver transplantations performed between 1979 and 2003. Clinical and laboratory information was obtained from the hospital files, and radiological studies were re-evaluated. Twenty-one possible risk factors for the development of AS (variables of donor, recipient, surgical procedure, and postoperative course) were analyzed in a univariate and stepwise multivariate model. Forty-seven grafts showed an anastomotic stricture: 42 in duct-to-duct anastomoses, and 5 in hepaticojejunal Roux-en-Y anastomoses. The cumulative risk of AS after 1, 5, and 10 years was 6.6%, 10.6%, and 12.3% respectively. Postoperative bile leakage (P = 0.001), a female donor/male recipient combination (P = 0.010), and the era of transplantation (P = 0.006) were independent risk factors for the development of an AS. In 47% of cases, additional (radiologically minor) nonanastomotic strictures were diagnosed. All patients were successfully treated by 1 or more treatment modalities. As primary treatment, endoscopic retrograde cholangiopancreaticography (ERCP) was successful in 24 of ...Continue Reading

References

Jan 1, 1995·Journal of Vascular and Interventional Radiology : JVIR·A B ZajkoK M Bron
Jun 1, 1996·Digestive Diseases and Sciences·C F GholsonJ C McDonald
Dec 27, 1996·Transplantation·B K BrooksG B Klintmalm
May 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R A ValleraP A Clavien
Oct 20, 1999·The Australian and New Zealand Journal of Surgery·G P JeffreyA K House
Jan 29, 2000·Gastrointestinal Endoscopy·D A SchwartzC J Gostout
Nov 2, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M A Moser, W J Wall
Mar 7, 2002·Current Treatment Options in Gastroenterology·Sanjay Jagannath, Anthony N. Kalloo
Dec 28, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·U BaccaraniF Bresadola
Apr 12, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Didier RoumilhacFrançois-René Pruvot
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maureen M J GuichelaarMichael R Charlton
Sep 6, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Paul J ThuluvathJohn Lee
Oct 31, 2003·Current Treatment Options in Gastroenterology·Deepak V. GopalMichael R. Lucey
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christian MoenchGerd Otto
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert SutcliffeNigel Heaton
Sep 25, 2004·Digestive Diseases and Sciences·Shawn St PeterDavid C Mulligan
Nov 2, 2004·Clinical Transplantation·Sanjeet ThethyO James Garden

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Citations

Sep 7, 2011·Nature Reviews. Gastroenterology & Hepatology·Sergio Zepeda-Gómez, Todd H Baron
Jun 2, 2011·Transplantation·Sanna Op den DriesRobert J Porte
Jan 19, 2008·World Journal of Gastroenterology : WJG·Maria-C LondoñoAndrés Cárdenas
Aug 13, 2009·World Journal of Gastroenterology : WJG·Emmanuelle D Williams, Peter V Draganov
Aug 5, 2011·Gut and Liver·Choong Heon Ryu, Sung Koo Lee
May 31, 2014·World Journal of Gastroenterology : WJG·Moustafa Mabrouk MouradSimon R Bramhall
Dec 2, 2014·Clinics in Liver Disease·Alejandro Fernández-SimonAndrés Cárdenas
Apr 23, 2010·Digestive Diseases and Sciences·Walid S AyoubPaul Martin
May 25, 2013·Digestive Diseases and Sciences·Jorge Cerecedo-RodriguezMichel Kahaleh
Nov 26, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Oct 10, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Calvin H Y ChanEric M Yoshida
Apr 2, 2013·Gastrointestinal Endoscopy Clinics of North America·John Y Nasr, Adam Slivka
Apr 2, 2013·Gastrointestinal Endoscopy Clinics of North America·Todd H Baron, Tomas Davee
Aug 18, 2012·Gastrointestinal Endoscopy·Thomas ZoepfPhilip Hilgard
Dec 14, 2011·Cirugía española·Laura LladóAntoni Rafecas
Aug 29, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Gun Hyung NaYoung Kyoung You
May 26, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Nalaka GunawansaStephen R Munn
Sep 7, 2011·Gastroenterology Clinics of North America·David H OusteckyKenneth D Rothstein
Aug 10, 2010·Gastroenterología y hepatología·Domingo BalderramoAndres Cardenas
Mar 5, 2016·Hepatology International·Kenneth S H Chok, Chung Mau Lo
Aug 5, 2010·Clinics in Liver Disease·Karen L KrokPaul J Thuluvath
May 11, 2010·Cirugía española·Laura LladóAntoni Rafecas
Oct 8, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P CantùR Penagini
Aug 30, 2008·Techniques in Vascular and Interventional Radiology·David G Buck, Albert B Zajko
Apr 29, 2008·Gastrointestinal Endoscopy·Terry L Jue, Joanne C Imperial
Jul 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Harm HoekstraRobert J Porte
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Charbel SandroussiDeborah J Verran
Aug 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jin Hyoung KimSung-Gyu Lee
Mar 28, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jeong Kyun SeoKyung Suk Suh

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