PMID: 2121905Dec 1, 1990Paper

Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease

Journal of Neurochemistry
Anthony H V SchapiraC D Marsden

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is thought to produce parkinsonism in humans and other primates through its inhibition of complex I. The recent discovery of mitochondrial complex I deficiency in the substantia nigra of patients with Parkinson's disease has provided a remarkable link between the idiopathic disease and the action of the neurotoxin MPTP. This article shows that complex I deficiency in Parkinson's disease is anatomically specific for the substantia nigra, and is not present in another neurodegenerative disorder involving the substantia nigra. Evidence is also provided to show that there is no correlation between L-3,4-dihydroxyphenylalanine therapy and complex I deficiency. These results suggest that complex I deficiency may be the underlying cause of dopaminergic cell death in Parkinson's disease.

References

Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·A H SchapiraC D Marsden
Mar 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
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Jun 3, 1989·Lancet·A H SchapiraC D Marsden
Feb 1, 1989·Journal of Neurochemistry·D T DexterC D Marsden
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C RichterB N Ames

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Citations

Apr 15, 1996·Journal of Neuroscience Research·S KöselM B Graeber
May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·B BarbiroliP Montagna
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·P MartinelliB Barbiroli
Apr 1, 2003·Annals of Neurology·William G TattonNadine Tatton
Apr 1, 2003·Annals of Neurology·Kevin St P McNaught, C Warren Olanow
Sep 1, 1991·Annals of Neurology·S J Boyson
Dec 1, 1994·Annals of Neurology·V M MannA H Schapira
Mar 1, 1996·Annals of Neurology·M GuA H Schapira
Dec 30, 2003·BioFactors·M Flint Beal, Clifford W Shults
Oct 15, 1995·Journal of Neuroscience Research·T FukushimaY Yamane
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·F DaganiT N Chase
Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·D BraviT N Chase
Oct 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·R DjaldettiE Melamed
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·D T DexterC D Marsden
Mar 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·A H Schapira
May 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·J M CooperA H Schapira
May 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·S PrzedborskiS Fahn
Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·J E AhlskogE Kokmen
Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·C I BlakeS J Boyson
May 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·M GuA H Schapira
Sep 26, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·S KöselM B Graeber
May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B A HolshouserH Masur
Jan 1, 1997·Journal of Neural Transmission·R K PearceC D Marsden
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·C MytilineouM D Yahr
Jul 1, 2005·Environmental Health and Preventive Medicine·Akiko SugawaraTetsuhito Fukushima
Feb 8, 2008·Bulletin of Experimental Biology and Medicine·L D Luk'yanovaA T Proshin
Mar 31, 2007·Cellular and Molecular Neurobiology·César A J RibeiroMoacir Wajner
Nov 12, 2009·Journal of Bioenergetics and Biomembranes·Mathieu MarellaAkemi Matsuno-Yagi

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