Anatomic distribution of pulmonary vascular compliance

Journal of Applied Physiology
R G PressonC A Dawson

Abstract

Previously, the pressure changes after arterial and venous occlusion have been used to characterize the longitudinal distribution of pulmonary vascular resistance with respect to vascular compliance using compartmental models. However, the compartments have not been defined anatomically. Using video microscopy of the subpleural microcirculation, we have measured the flow changes in approximately 40-micron arterioles and venules after venous, arterial, and double occlusion maneuvers. The quasi-steady flows through these vessels after venous occlusion permitted an estimation of the compliance in three anatomic segments: arteries > 40 microns, veins > 40 microns, and vessels < 40 microns in diameter. We found that approximately 65% of the total pulmonary vascular compliance was in vessels < 40 microns, presumably mostly capillaries. The transient portions of the pressure and flow data after venous, arterial, and double occlusion were consistent with most of the arterial compliance being upstream from most of the arterial resistance and most of the venous compliance being downstream from most of the venous resistance.

References

Sep 1, 1992·Journal of Applied Physiology·S H AudiJ H Linehan
Jul 1, 1992·Journal of Applied Physiology·T S Hakim
May 1, 1991·Journal of Applied Physiology·S H AudiJ H Linehan
Feb 1, 1991·Journal of Applied Physiology·T S Hakim
Sep 1, 1989·Journal of Applied Physiology·T S Hakim, S Kelly
Jan 1, 1988·Journal of Applied Physiology·C A DawsonT A Bronikowski
Jul 1, 1986·Journal of Applied Physiology·M I TownsleyA E Taylor
Jul 1, 1986·Journal of Applied Physiology·R G BrowerS Permutt
Mar 1, 1969·Journal of Applied Physiology·W W Wagner
Nov 1, 1984·Microvascular Research·T A BronikowskiC A Dawson
Jan 1, 1982·Annals of the New York Academy of Sciences·C A DawsonD A Rickaby
Mar 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T S HakimH K Chang
Jul 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J H LinehanD A Rickaby
Aug 1, 1995·Journal of Applied Physiology·C C HangerW W Wagner
Aug 1, 1994·Journal of Applied Physiology·R Z Gan, R T Yen
Nov 1, 1993·Journal of Applied Physiology·S C HillierW W Wagner
Mar 1, 1993·Microvascular Research·J L UnthankH G Bohlen
Apr 1, 1997·Journal of Applied Physiology·S C HillierW W Wagner
Jul 1, 1964·Journal of Applied Physiology·J B WESTA NAIMARK

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Citations

Feb 4, 1999·Journal of Applied Physiology·C A DawsonJ H Linehan
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·D NegriniG Miserocchi
Nov 2, 2013·Journal of Applied Physiology·J Christopher BouwmeesterJohn V Tyberg
Jul 27, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Fuyou LiangHao Liu
May 9, 2016·International Journal for Numerical Methods in Biomedical Engineering·Daniele E SchiavazziAlison L Marsden
Sep 10, 2003·Journal of Applied Physiology·Robert L ConhaimBruce A Harms
Mar 24, 2006·AJR. American Journal of Roentgenology·Anthony J YunAnthony N Gerber
Sep 6, 2005·The Tohoku Journal of Experimental Medicine·Suguru WatanabeHironobu Sasano
Jan 25, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Chiara CorsiniUNKNOWN Modeling of Congenital Hearts Alliance (MOCHA) Investigators
Aug 26, 2016·Annals of Biomedical Engineering·Aiping LiuNaomi C Chesler
Oct 5, 2018·Biomechanics and Modeling in Mechanobiology·M Umar QureshiMette S Olufsen
Dec 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·S P WrightS Mak
Apr 10, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Reda E Girgis, Marius M Hoeper
Sep 15, 2019·Seminars in Thoracic and Cardiovascular Surgery·Ethan KungUNKNOWN Modeling of Congenital Hearts Alliance (MOCHA)+ Investigators
Jan 16, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Bengt JohanssonPhilip J Kilner

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