Abstract
Sessile serrated adenomas/polyps (SSA/Ps) have been increasingly studied during the last 10 years. However, their detailed anatomic distribution pattern has not been studied, especially given newer (broader) criteria for the diagnosis. To characterize the anatomic distribution of SSA/P with and without cytologic dysplasia and to assess the demographics of these patients in a nationwide database. We retrospectively analyzed the database of Miraca Life Sciences Research Institute for a 1-year period. Patients with a diagnosis of SSA/P, SSA/P with low-grade cytologic dysplasia (SSA/P-LGD), SSA/P with high-grade cytologic dysplasia (SSA/P-HGD), or SSA/P with adenocarcinoma (SSA/P-ACA) were retrieved, and patients' age, sex, and specific anatomic location were analyzed. A total of 11,201 patients were identified, of which 10,646 (95.0%) had SSA/P, 514 (4.6%) had SSA/P-LGD, 39 (0.35%) had SSA/P-HGD, and 2 (0.018%) had SSA/P-ACA. All SSA/Ps and more advanced lesions were significantly more common in the proximal colon-SSA/P (61.2%), SSA/P-LGD (61.2%), SSA/P-HGD (80%), and SSA/P-ACA (100%)-than in either the transverse (18.8%, 17.8%, 10.0%, and 0%, respectively) or the distal (19.9%, 21.0%, 10.0%, and 0%, respectively) colon, P < .001....Continue Reading
References
Mar 1, 1996·Gastroenterology·E Torlakovic, D C Snover
Dec 28, 2002·The American Journal of Surgical Pathology·Emina TorlakovicJahn M Nesland
Feb 20, 2004·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·F Pérez RoldánF Ruiz Carrillo
Sep 30, 2005·American Journal of Clinical Pathology·Dale C SnoverKenneth P Batts
Aug 30, 2006·American Journal of Clinical Pathology·Todd B SheridanElizabeth Montgomery
Nov 15, 2006·Gastroenterology·Kevin J SpringBarbara A Leggett
Nov 24, 2006·The American Journal of Surgical Pathology·Michael J O'BrienFrancis A Farraye
Feb 28, 2008·The American Journal of Surgical Pathology·Sun M ChungRhonda K Yantiss
Apr 4, 2008·Gastroenterology·Bernard LevinUNKNOWN American College of Radiology Colon Cancer Committee
Sep 9, 2008·Gastroenterology·William M Grady, John M Carethers
Jan 8, 2009·Journal of Clinical Pathology·N J CarrR L Ward
Aug 28, 2009·Gut·Karam S BoparaiEvelien Dekker
Nov 17, 2009·Gastroenterology·Hermann BrennerMichael Hoffmeister
Apr 28, 2010·Gastroenterology·Barbara Leggett, Vicki Whitehall
May 13, 2010·Histopathology·Rish K PaiAmy E Noffsinger
Jun 16, 2010·Journal of Clinical Pathology·Richard H LashChristopher M Schuler
Jul 10, 2010·Virchows Archiv : an International Journal of Pathology·Daniela E AustUNKNOWN Members of the Working Group GI-Pathology of the German Society of Pathology
Aug 19, 2010·The American Journal of Gastroenterology·Jeremy T HetzelFrancis A Farraye
Nov 4, 2010·The American Journal of Gastroenterology·Christopher S HuangMichael J O'Brien
Jan 11, 2011·American Journal of Clinical Oncology·Lee ChengXianglin L Du
Feb 18, 2011·Journal of Clinical Gastroenterology·Joseph Carl AndersonPetr Protiva
Feb 24, 2012·The New England Journal of Medicine·Ann G ZauberJerome D Waye
Mar 7, 2012·Annals of Internal Medicine·Amir QaseemUNKNOWN Clinical Guidelines Committee of the American College of Physicians
Jun 2, 2012·World Journal of Gastroenterology : WJG·Carla GuarinosRodrigo Jover
Jun 20, 2012·The American Journal of Gastroenterology·Douglas K RexJames Church
Dec 5, 2012·ISRN Oncology·Josep J Centelles
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 24, 2013·Histopathology·Mark BettingtonVicki Whitehall
Mar 6, 2013·American Journal of Epidemiology·Andrea N Burnett-HartmanPolly A Newcomb
Oct 10, 2013·Diseases of the Colon and Rectum·Kory W JaspersonN Jewel Samadder
Citations
Feb 24, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Seth SweetserFrank A Sinicrope
Mar 18, 2016·Digestion·Martin Floer, Tobias Meister
Jul 29, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cheng LiuChristophe Rosty
Mar 16, 2018·Journal of Digestive Diseases·Tian Yu LiuHai Long Cao
Dec 23, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Odise CenajRobert D Odze
Dec 16, 2018·Journal of Gastroenterology and Hepatology·Leonardo Zorron Cheng Tao PuRajvinder Singh
Mar 3, 2019·Histopathology·Mark BettingtonChristophe Rosty
Feb 18, 2016·Oncotarget·Jung Ho KimGyeong Hoon Kang
Dec 17, 2015·Journal of Clinical Gastroenterology·Robert M Genta
Mar 19, 2019·Gastroenterology Research and Practice·A J McCarthyK Sheahan
Apr 8, 2020·BioMed Research International·Gitana Maria AcetoMaria Cristina Curia
Apr 27, 2017·Digestive Diseases and Sciences·Ronald G RachoMichael B Wallace
Mar 10, 2019·Scientific Reports·Ki-Hyun KimYoung-Eun Joo
Apr 28, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rish K PaiChristophe Rosty
Mar 12, 2019·Canadian Journal of Gastroenterology & Hepatology·Shou-Jiang Tang, Ruonan Wu
Nov 4, 2020·Journal of Gastroenterology and Hepatology·Shahzaib AnwarErin L Symonds
Mar 23, 2017·Cancer Prevention Research·Shahrooz RashtakFrank A Sinicrope
Jul 20, 2019·Gastroenterology·Seth D Crockett, Iris D Nagtegaal
Jan 16, 2021·Gut Microbes·Lauren DeDeckerKatrine Whiteson
Mar 23, 2020·Gastroenterology·Reinier G S MeesterUri Ladabaum
Apr 30, 2021·Clinical Endoscopy·Yi Yuan TanMalcolm Teck Kiang Tan
Sep 21, 2021·American Journal of Clinical Pathology·Kenneth P BattsLawrence J Burgart