Anatomic distribution of sessile serrated adenoma/polyp with and without cytologic dysplasia

Archives of Pathology & Laboratory Medicine
Juliana F YangQinghua Yang

Abstract

Sessile serrated adenomas/polyps (SSA/Ps) have been increasingly studied during the last 10 years. However, their detailed anatomic distribution pattern has not been studied, especially given newer (broader) criteria for the diagnosis. To characterize the anatomic distribution of SSA/P with and without cytologic dysplasia and to assess the demographics of these patients in a nationwide database. We retrospectively analyzed the database of Miraca Life Sciences Research Institute for a 1-year period. Patients with a diagnosis of SSA/P, SSA/P with low-grade cytologic dysplasia (SSA/P-LGD), SSA/P with high-grade cytologic dysplasia (SSA/P-HGD), or SSA/P with adenocarcinoma (SSA/P-ACA) were retrieved, and patients' age, sex, and specific anatomic location were analyzed. A total of 11,201 patients were identified, of which 10,646 (95.0%) had SSA/P, 514 (4.6%) had SSA/P-LGD, 39 (0.35%) had SSA/P-HGD, and 2 (0.018%) had SSA/P-ACA. All SSA/Ps and more advanced lesions were significantly more common in the proximal colon-SSA/P (61.2%), SSA/P-LGD (61.2%), SSA/P-HGD (80%), and SSA/P-ACA (100%)-than in either the transverse (18.8%, 17.8%, 10.0%, and 0%, respectively) or the distal (19.9%, 21.0%, 10.0%, and 0%, respectively) colon, P < .001....Continue Reading

References

Mar 1, 1996·Gastroenterology·E Torlakovic, D C Snover
Dec 28, 2002·The American Journal of Surgical Pathology·Emina TorlakovicJahn M Nesland
Feb 20, 2004·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·F Pérez RoldánF Ruiz Carrillo
Sep 30, 2005·American Journal of Clinical Pathology·Dale C SnoverKenneth P Batts
Sep 9, 2008·Gastroenterology·William M Grady, John M Carethers
Nov 17, 2009·Gastroenterology·Hermann BrennerMichael Hoffmeister
Apr 28, 2010·Gastroenterology·Barbara Leggett, Vicki Whitehall
Jun 16, 2010·Journal of Clinical Pathology·Richard H LashChristopher M Schuler
Jul 10, 2010·Virchows Archiv : an International Journal of Pathology·Daniela E AustUNKNOWN Members of the Working Group GI-Pathology of the German Society of Pathology
Aug 19, 2010·The American Journal of Gastroenterology·Jeremy T HetzelFrancis A Farraye
Nov 4, 2010·The American Journal of Gastroenterology·Christopher S HuangMichael J O'Brien
Jan 11, 2011·American Journal of Clinical Oncology·Lee ChengXianglin L Du
Feb 18, 2011·Journal of Clinical Gastroenterology·Joseph Carl AndersonPetr Protiva
Feb 24, 2012·The New England Journal of Medicine·Ann G ZauberJerome D Waye
Mar 7, 2012·Annals of Internal Medicine·Amir QaseemUNKNOWN Clinical Guidelines Committee of the American College of Physicians
Jun 2, 2012·World Journal of Gastroenterology : WJG·Carla GuarinosRodrigo Jover
Jun 20, 2012·The American Journal of Gastroenterology·Douglas K RexJames Church
Dec 5, 2012·ISRN Oncology·Josep J Centelles
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 24, 2013·Histopathology·Mark BettingtonVicki Whitehall
Mar 6, 2013·American Journal of Epidemiology·Andrea N Burnett-HartmanPolly A Newcomb
Oct 10, 2013·Diseases of the Colon and Rectum·Kory W JaspersonN Jewel Samadder

❮ Previous
Next ❯

Citations

Feb 24, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Seth SweetserFrank A Sinicrope
Jul 29, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cheng LiuChristophe Rosty
Mar 16, 2018·Journal of Digestive Diseases·Tian Yu LiuHai Long Cao
Dec 23, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Odise CenajRobert D Odze
Dec 16, 2018·Journal of Gastroenterology and Hepatology·Leonardo Zorron Cheng Tao PuRajvinder Singh
Mar 19, 2019·Gastroenterology Research and Practice·A J McCarthyK Sheahan
Apr 8, 2020·BioMed Research International·Gitana Maria AcetoMaria Cristina Curia
Apr 28, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rish K PaiChristophe Rosty
Mar 12, 2019·Canadian Journal of Gastroenterology & Hepatology·Shou-Jiang Tang, Ruonan Wu
Nov 4, 2020·Journal of Gastroenterology and Hepatology·Shahzaib AnwarErin L Symonds
Mar 23, 2017·Cancer Prevention Research·Shahrooz RashtakFrank A Sinicrope
Jul 20, 2019·Gastroenterology·Seth D Crockett, Iris D Nagtegaal
Jan 16, 2021·Gut Microbes·Lauren DeDeckerKatrine Whiteson
Mar 23, 2020·Gastroenterology·Reinier G S MeesterUri Ladabaum
Apr 30, 2021·Clinical Endoscopy·Yi Yuan TanMalcolm Teck Kiang Tan
Sep 21, 2021·American Journal of Clinical Pathology·Kenneth P BattsLawrence J Burgart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.