Anatomic extent of colitis and disease severity are not predictors of pouchitis after restorative proctocolectomy for mucosal ulcerative colitis

Techniques in Coloproctology
N SengulM Berho

Abstract

Pouchitis is a common complication following restorative proctocolectomy with ileal pouch anal anastomosis (RPC-IPAA) for mucosal ulcerative colitis (MUC). The aim of this study was to determine if perioperative anatomic extent and severity of disease are predictors of pouchitis. All consecutive patients who underwent RPC-IPAA for MUC between 1988 and 2002 were retrospectively studied. Pouchitis was classified as acute, recurrent or refractory. Colectomy specimen slides were histopathologically evaluated by a single blinded pathologist (MB), who assessed extent and severity of disease. Of 112 patients assessed, 70 (62.5%) had some form of pouchitis at a median follow-up of 38 months (range, 1-204 months). No association was found between the extent or severity of disease and subsequent development of acute or chronic pouchitis. A positive correlation was found between the histopathologic score and the occurrence of clinical pouchitis (p=0.014). The presence of colonic metaplasia in the pouch biopsy was significantly correlated with a histopathologic diagnosis of pouchitis (p<0.0001, r=-0.449). Following RPC for MUC, the extent and severity of disease do not predict the subsequent development of pouchitis.

Citations

Aug 18, 2009·Inflammatory Bowel Diseases·Darrell S PardiPaolo Gionchetti
Jun 19, 2012·Clinics and Research in Hepatology and Gastroenterology·I H KalkanN Şaşmaz
Mar 19, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K-K TanM J Solomon
Jun 1, 2016·Journal of Pediatric Gastroenterology and Nutrition·Rajmohan DharmarajJoshua Noe
Apr 20, 2007·The British Journal of Surgery·M ScarpaW A Bemelman
Sep 13, 2015·Journal of Speech, Language, and Hearing Research : JSLHR·Scott Seeman, Rebecca Sims
Mar 6, 2016·European Journal of Gastroenterology & Hepatology·George Dafnis
Nov 21, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Danujan SriranganathanJonathan P Segal

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