Anatomic-Functional Correlates in Lesions of Retinal Vein Occlusion.

Investigative Ophthalmology & Visual Science
Meiaad KhayatNoemi Lois

Abstract

To evaluate anatomic-functional associations at sites of retinal lesions in retinal vein occlusion (RVO). This pilot, prospective, observational study was conducted at the Northern Ireland Clinical Research Facility (NICRF) of Queen's University and the Belfast Health and Social Care Trust, Northern Ireland, between August 1, 2018, and September 30, 2019. The study included 10 treatment-naïve patients with RVO (10 RVO eyes and 10 fellow eyes). There were 81 points/sites assessed for each eye at baseline; six patients were re-assessed 6 months after anti-vascular endothelial growth factor therapy at the same locations. We investigated associations between retinal sensitivity and presence of structural RVO lesions, including retinal ischemia, hemorrhages, intraretinal fluid (IRF) and subretinal fluid outside the foveal/parafoveal regions. Comparisons were made between RVO eyes and fellow eyes at baseline, and between RVO eyes at baseline and at 6 months after treatment. Regression models were used to investigate anatomic-functional associations. At baseline, strong associations were found between reduced retinal sensitivity and presence of ischemia (estimate = -2.08 dB; P < 0.001), intraretinal fluid (estimate = -7.82 dB; P < 0.0...Continue Reading

References

May 24, 2011·Survey of Ophthalmology·Justis P Ehlers, Sharon Fekrat
Nov 19, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Masafumi OtaNagahisa Yoshimura
Sep 22, 2017·JCI Insight·Yuanyuan LiuPeter A Campochiaro

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MAIA
R Foundation for Statistical Computing
SPSS ( Statistical Package for the Social Sciences )
R

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