PMID: 8946336Nov 6, 1996Paper

Anatomical and electrophysiological comparison of the sensory innervation of bronchial and tracheal parasympathetic ganglion neurons

Journal of the Autonomic Nervous System
A C MyersW Kummer

Abstract

Anatomical and electrophysiological techniques were used to examine differences in the level of sensory nerve terminals localized in parasympathetic ganglia in guinea pig trachea and bronchus. We quantified substance-P-immunoreactive nerve terminal profiles within the ganglia and the amplitude of capsaicin-sensitive depolarization (slow excitatory postsynaptic potential or sEPSP) evoked by vagus (bronchial) or recurrent (tracheal) nerve-stimulation. Substance-P-immunoreactive axon profiles per intrinsic tracheal neuron were fewer in number than per bronchial ganglion neuron. The average amplitude and duration of the capsaicin-sensitive sEPSPs were similar in tracheal and bronchial ganglion neurons. Furthermore, capsaicin evoked a nearly equal depolarization of bronchial and tracheal ganglion neurons. The sEPSPs were reduced in both areas by a selective neurokinin-3 receptor antagonist. SR142801. These results demonstrate that although the number of sensory nerve fibers in tracheal ganglia are significantly less than those in the bronchus, this did not translate to an obvious physiological difference in sEPSP amplitude.

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Citations

Jun 21, 2006·Cell and Tissue Research·Ian L Gibbins, Judy L Morris
Mar 15, 2002·Current Allergy and Asthma Reports·Bradley J Undem, Michael J Carr
Mar 10, 2001·Respiration Physiology·A C Myers
Feb 13, 2001·British Journal of Pharmacology·H IshibashiK Takahama
Jun 29, 2001·Clinical and Experimental Pharmacology & Physiology·S W WhiteD B Cottee
Oct 8, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Michael J Carr, Bradley J Undem
Nov 24, 1999·Allergy·B J UndemD D Hunter
Jul 13, 1999·Equine Veterinary Journal·I M SoneaN E Robinson
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·R KajekarA C Myers
Oct 13, 2004·American Journal of Respiratory and Critical Care Medicine·Allen C MyersDouglas W P Hay
Oct 22, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hitoshi Ishibashi, Mari Umezu
May 6, 2004·Archives of Histology and Cytology·Dwi Liliek KusindartaYoshio Yamamoto
Nov 11, 2008·Regulatory Peptides·Nuray Erin, Ozkan Ulusoy
Oct 1, 2008·Autonomic Neuroscience : Basic & Clinical·Vânia C G FurlaniEdson A Liberti
Feb 20, 2007·European Journal of Pharmacology·Emmanuel NalineNelly Frossard
Oct 6, 2004·Allergy·D A GronebergA Fischer
Mar 3, 2004·British Journal of Pharmacology·Céline RougetCharles Advenier
Jun 24, 2004·European Journal of Pharmacology·Francisco M PintoM Luz Candenas
Sep 2, 2006·Vascular Pharmacology·Brendan J Canning
Aug 28, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jian-Rong ZhouKazuo Takahama
Jun 10, 2016·Physiological Reviews·Stuart B Mazzone, Bradley J Undem
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brendan J CanningAllen C Myers
Feb 9, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·J J FontánB N Mora
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L ZhangD B Hoover
Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·R Kajekar, A C Myers
Jul 1, 2020·Journal of Anatomy·Martin M BertrandJanet R Keast
Oct 10, 2002·Annals of Medicine·J Julio Pérez Fontan

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