Anatomical and Functional Computed Tomography for Diagnosing Hemodynamically Significant Coronary Artery Disease: A Meta-Analysis

JACC. Cardiovascular Imaging
Csilla CelengRichard A P Takx

Abstract

This meta-analysis determined the diagnostic performance of coronary computed tomography (CT) angiography (CTA), CT myocardial perfusion (CTP), fractional flow reserve CT (FFRCT), the transluminal attenuation gradient (TAG), and their combined use with CTA versus FFR as a reference standard for detection of hemodynamically significant coronary artery disease (CAD). CTA provides excellent anatomic, albeit limited functional information for the evaluation of CAD. Recently, various functional CT techniques emerged to assess the hemodynamic consequences of CAD. This meta-analysis was performed in adherence to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. PubMed, EMBASE, and Web of Science were searched from inception until September 7, 2017. Bayesian random effects analysis was used to compute pooled sensitivity, specificity, and the summary receiver-operating characteristic curve of the index tests and compare them with the FFR as a reference standard. Analyses were performed on vessel and patient levels. Because CTA has excellent sensitivity, specificity was considered most relevant. Individual FFRCT values were collected. Overall, 54 articles and 5,330 patients were included. At vess...Continue Reading

Citations

Jun 4, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Alexia Rossi, Giuseppe Ferrante
Sep 1, 2019·Journal of Cardiovascular Translational Research·Floor GroepenhoffHester M den Ruijter
Oct 4, 2019·Clinical Physiology and Functional Imaging·Ernesto ForteFilippo Cademartiri
Feb 26, 2020·Nature Reviews. Cardiology·Marc DeweyUNKNOWN Quantitative Cardiac Imaging Study Group
Oct 24, 2019·European Heart Journal Cardiovascular Imaging·Antti SarasteJuhani Knuuti
Feb 7, 2020·Japanese Journal of Radiology·Yuki TanabePrabhakar Rajiah
Nov 26, 2020·The British Journal of Radiology·Melissa A DaubertLynne Koweek
Aug 9, 2020·JACC. Cardiovascular Imaging·Leslee ShawY Chandrashekhar
Dec 19, 2020·Journal of the American College of Cardiology·Leslee J Shaw, Y Chandrashekhar
Dec 9, 2020·Journal of Clinical Medicine·Francesca BaessatoGianluca Pontone
Oct 15, 2019·JACC. Cardiovascular Imaging·Tim Leiner, Richard A P Takx
Jan 16, 2020·Radiology. Cardiothoracic Imaging·Jonathan R Weir-McCall, Timothy A Fairbairn
May 10, 2020·JACC. Cardiovascular Imaging·Eike Nagel, Y Chandrashekhar
May 5, 2021·JAMA : the Journal of the American Medical Association·Parag H Joshi, James A de Lemos
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Jun 6, 2021·International Journal of Cardiology·Jesse Habets
Jul 31, 2021·American Journal of Preventive Cardiology·Harold E BaysPeter P Toth
Aug 14, 2021·Journal of the American College of Cardiology·Patrick W SerruysYoshinobu Onuma
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Sep 6, 2020·Journal of Thoracic Imaging·Kevin KaliszBradley D Allen
Dec 16, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J PeperM J Swaans

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