PMID: 3747730Sep 1, 1986Paper

Anatomical changes of the GABAergic system in the inferior colliculus of the genetically epilepsy-prone rat

Life Sciences
R C Roberts, C E Ribak

Abstract

The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of rat. GAD-positive neurons are abundant in the IC and a significant increase in the number of GAD-positive neurons occurs in the GEPR as compared to the SD in all three subdivisions. However, the most pronounced difference occurs in the ventral lateral portion of the central nucleus, where there is a selective increase in the small (200%) and medium-sized (90%) GABAergic somata (10-15 microns in diameter and 15-25 microns in diameter, respectively). As determined from Nissl preparations an increase in total numbers of neurons also occurs. Thus, a 100% increase in the number of small neurons and a 30% increase in the number of medium-sized neurons occur in the adult GEPR as compared to the SD rat. A statistically significant increase in the numbers of small neurons also occurred in the IC of the young GEPR. At 4 days of age, a 55% increase in the number of small neurons was found, and at 10 days of age this increase wa...Continue Reading

References

Jan 1, 1983·Zdravotnické aktuality,·Z Servít, M Kristof

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Citations

Aug 1, 1989·Molecular and Chemical Neuropathology·H E Laird
Jan 25, 1990·European Journal of Pharmacology·K A Smith, G G Bierkamper
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·A SmolenP C Han
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Jan 1, 1994·Brain Research Bulletin·P C JobeJ W Dailey
Oct 1, 1991·Epilepsy Research·R S Fisher
Oct 1, 1992·Epilepsy Research·M Pierson, S L Liebmann
Jan 1, 1993·Epilepsia·J R Buchhalter

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