PMID: 6164447Apr 6, 1981Paper

Anatomical evidence for the influence of degenerating pathways on regenerating optic fibers following surgical manipulations in the visual system of the goldfish

Brain Research
R Y Lo, R L Levine

Abstract

We have used [3H]proline radioautography to trace regenerating optic fibers in the goldfish following: (1) the removal of the right tectal lobe and the right eye, and (2) the removal of both tectal lobes. Our results indicate that following the removal of the right tectal lobe and the right eye, both the denervated tectal efferent pathways, and the denervated visual pathways and terminal zones of the enucleated eye were penetrated by the regenerating optic fibers. In addition, following bilateral lobectomy, the denervated tectal efferent pathways were bilaterally penetrated by the regenerating fibers. Since, in both types of operations, these denervated pathways and terminal zones should undergo degeneration, our results support the suggestion that the presence of degenerating axonal debris and proliferating glia may play an important role in guiding regenerating optic fibers in the visual system of the goldfish.

References

Apr 1, 1979·The Journal of Comparative Neurology·B G Grover, S C Sharma
May 15, 1976·The Journal of Comparative Neurology·P G ClarkeW M Cowan
Nov 7, 1975·Brain Research·R L Levine, M Jacobson
Jan 1, 1976·The Journal of Comparative Neurology·C M Sligar, T J Voneida
Feb 1, 1976·The Journal of Cell Biology·L Landmesser, G Pilar
Jan 15, 1976·The Journal of Comparative Neurology·S O Ebbesson, H Vanegas
May 15, 1980·The Journal of Comparative Neurology·R Y Lo, R L Levine

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