Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

Neuroscience
H L MelroseMatthew J Farrer

Abstract

Mutations in leucine-rich repeat kinase 2 (LRRK2) have recently been identified in autosomal dominant late-onset Parkinson's disease. Expression of LRRK2 has previously been reported in brain; however, no precise anatomical information is yet available. We have performed in situ hybridization and quantitative reverse transcription polymerase chain reaction to map LRRK2 mRNA expression in mouse brain. We find LRRK2 is highly expressed in the striatum, cortex and olfactory tubercle; however, little or no expression is found in the substantia nigra, where dopaminergic neurons preferentially degenerate in Parkinson's disease. These findings suggest that LRRK2 mRNA is expressed in dopamine-receptive areas rather than in the dopamine-synthesizing neurons. Consistent with a role LRRK2 in Parkinson's disease, dysfunction of leucine-rich repeat kinase 2 protein in dopamine-innervated areas may to lead to altered dopaminergic neurotransmission and degeneration of the nigro-striatal pathway.

References

Feb 2, 2000·Neuroscience and Biobehavioral Reviews·D ValloneE Borrelli
Sep 30, 2000·Brain Research. Brain Research Reviews·A J ReynoldsI A Hendry
Sep 15, 2005·Neurology·M FarrerD M Maraganore

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Citations

Apr 28, 2006·Experimental Brain Research·Heather L MelroseMatthew J Farrer
Jan 15, 2009·Acta Neuropathologica·Gabriel Santpere, Isidre Ferrer
Mar 24, 2012·Current Neurology and Neuroscience Reports·Elpida Tsika, Darren J Moore
Mar 11, 2009·Antioxidants & Redox Signaling·Saurabh Sen, Andrew B West
Apr 23, 2013·Stem Cells and Development·Lamia'a BahnassawyJens C Schwamborn
Nov 30, 2007·BMC Neuroscience·Saskia BiskupAndrew B West
Nov 30, 2012·Journal of Neuroinflammation·Daniel F MarkerHarris A Gelbard
May 19, 2012·Journal of Neuroinflammation·Elisa GreggioLuigi Bubacco
Dec 2, 2006·Molecular Neurodegeneration·Xiongwei ZhuShu G Chen
May 16, 2013·PloS One·Florian GiesertWolfgang Wurst
May 24, 2011·Parkinson's Disease·Tianxia LiWanli W Smith
Feb 20, 2009·Future Neurology·Heather Melrose
Jun 5, 2013·Neurochemical Research·Hardy J Rideout, Leonidas Stefanis
Jun 25, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Iakov N Rudenko, Mark R Cookson
Dec 22, 2007·Neuro-Signals·Benoit I Giasson, Vivianna M Van Deerlin
Aug 5, 2015·Journal of Clinical Medicine·Roger TorrentAntonella Consiglio
Oct 6, 2006·Journal of Neuropathology and Experimental Neurology·Judith MiklossyPatrick L McGeer
Aug 15, 2009·Journal of Neuropathology and Experimental Neurology·Shinji HigashiEizo Iseki
Apr 21, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sabrina ZechelOliver von Bohlen Und Halbach
Jan 19, 2010·Biochemical and Biophysical Research Communications·Tatsunori MaekawaFumiya Obata
Jul 8, 2008·Parkinsonism & Related Disorders·Darren J Moore
Jul 19, 2008·Neuroscience Letters·Baek-Soo HanKwang-Soo Kim
Nov 26, 2008·Journal of Neuroscience Research·Payal N GandhiAmy L Wilson-Delfosse
Nov 1, 2007·Neuropathology and Applied Neurobiology·J Alegre-AbarrateguiR Wade-Martins
Jul 14, 2006·Journal of Neurochemistry·Asa Abeliovich, M Flint Beal
Jun 15, 2006·Journal of Neurochemistry·Jean-Marc TaymansVeerle Baekelandt
Mar 19, 2014·The Journal of Comparative Neurology·Andrew B WestLaura A Volpicelli-Daley
Oct 10, 2006·Trends in Molecular Medicine·A Wood-KaczmarN W Wood
Jun 6, 2006·Neurobiology of Disease·Elisa GreggioMark R Cookson
Apr 18, 2006·Trends in Neurosciences·Ignacio F MataKathleen A Gallo
Jul 27, 2011·Biochemical Society Transactions·Sara J Johnson, Richard Wade-Martins
Sep 20, 2012·Biochemical Society Transactions·Giovanna SannaCiro Iaccarino

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