Anatomical localization of radiocolloid tracer deposition affects outcome of sentinel node procedures in prostate cancer

European Journal of Nuclear Medicine and Molecular Imaging
C M de KorneH G van der Poel

Abstract

Diagnostic imaging modalities have moderate sensitivity for the identification of lymph node (LN) metastases in prostate cancer (PCa) patients. Mapping the lymphatic drainage from the prostate can help to identify the LNs directly draining from the tumour (sentinel nodes (SNs)); the LNs stated to have the highest chance of containing metastatic cancer cells. Although the lymphatic drainage may differ between segments within the prostate, the location of the primary tumour is not routinely taken into account during peripheral zone-aimed tracer administration. This study evaluates whether linking the SN procedure to the primary cancer deposits increases the identification accuracy of lymphatic metastases. Sixty-seven PCa patients, scheduled for robot-assisted laparoscopic prostatectomy (RALP) and extended lymph node dissection (ePLND) with subsequent SN biopsy, were included in this retrospective study. After injection of the hybrid tracer ICG-99mTc-nanocolloid in the prostate, SN mapping was performed based on lymphoscintigraphy and SPECT/CT. SNs were resected using a combination of radio- and fluorescence guidance. Pathology was used to determine the primary tumour location and metastatic spread. Fluorescence imaging of paraffi...Continue Reading

References

Apr 1, 1992·Archives of Surgery·D L MortonA J Cochran
Jul 18, 2001·Annals of Surgical Oncology·O E NiewegB B Kroon
Sep 26, 2006·European Urology·Dorothea WeckermannRolf Harzmann
Feb 14, 2007·The Journal of Urology·Dorothea WeckermannRolf Harzmann
Jan 25, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Blanca PañoCarlos Nicolau
May 31, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tessa BuckleFijs W B van Leeuwen
Jul 17, 2012·European Urology·Steven JoniauHein Van Poppel
Mar 16, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nynke S van den BergFijs W B van Leeuwen
Apr 19, 2016·Clinical Nuclear Medicine·Girolamo TartaglioneMark McGurk
Nov 18, 2016·Der Urologe. Ausg. A·H G van der PoelS Horenblas
Dec 27, 2017·Current Opinion in Urology·Matthias N van OosteromFijs W B van Leeuwen
Apr 27, 2018·European Journal of Nuclear Medicine and Molecular Imaging·G H KleinJanF W B van Leeuwen
Sep 6, 2018·European Urology·Marthe LøvfRolf I Skotheim
Sep 22, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Margret SchotteliusHans-Jürgen Wester
Jan 16, 2019·Nature Reviews. Urology·Fijs W B van LeeuwenTobias Maurer

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Citations

Aug 31, 2020·International Journal of Radiation Oncology, Biology, Physics·William A HallColleen A F Lawton
Jan 27, 2021·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Daphne D RietbergenTessa Buckle

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