Anatomically based simulation of hepatic perfusion in the human liver

International Journal for Numerical Methods in Biomedical Engineering
Renfei MaSoroush Safaei

Abstract

Liver structures of a healthy subject are digitised and segmented from computed tomography (CT) images, and hepatic perfusion is modelled in the hepatic artery and portal vein of the healthy subject with structured tree-based outflow boundary conditions. This self-similar structured tree is widely used in the literature, eg, blood flow simulation in larger systemic arteries and cerebral circulation, and is used in this study to model the effect of the smaller hepatic arteries and arterioles, as well as the smaller hepatic portal veins and portal venules. Physiologically reasonable results are obtained. Since the structured tree terminates at the size of the microvasculature system in liver lobules, the structured tree boundary condition will enable the proposed organ-level model of hepatic arterial flow to be easily connected to tissue-level models of liver lobules. Blood flow in the hepatic vein is also modelled in this subject with three-element Windkessel model as outflow boundary conditions. The benefit of integrating the perfusion in all hepatic vascular vessels is that it helps us analyse some complicated clinical phenomenon more efficiently, eg, one possible application is to obtain the portal pressure gradient (PPG) to ...Continue Reading

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Citations

Nov 7, 2019·International Journal for Numerical Methods in Biomedical Engineering·Renfei MaSoroush Safaei
Jul 29, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Megan J ChambersMette S Olufsen
Oct 3, 2020·Scientific Reports·Sylvie LorenteAczel Sanchez-Cedillo
Feb 21, 2021·International Journal for Numerical Methods in Biomedical Engineering·Zeng LinXiao-Chuan Cai
Oct 12, 2021·Frontiers in Physiology·Seyed M SeyedpourTim Ricken
Dec 7, 2021·Frontiers in Physiology·Aimee M Torres RojasAczel Sanchez-Cedillo

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