Anatomically specific patterns of glial activation in the periaqueductal gray of the sub-population of rats showing pain and disability following chronic constriction injury of the sciatic nerve

Neuroscience
David MorK A Keay

Abstract

Neuropathic pain conditions for which treatment is sought are characterized by complex behavioural disturbances, as well as "pain." Recent studies using chronic constriction injury of the sciatic nerve have shown that rats develop three distinct patterns of disability characterized by changes in social-interactions and sleep-wake cycle behaviours post-injury: (i) Persistent Disability, (ii) Transient Disability and (iii) No Disability. These patterns occur despite all rats showing identical levels of allodynia and hyperalgesia (i.e., pain). In rats, social-interactions and sleep-wake cycle behaviours are regulated in part, by neural networks, which converge on the periaqueductal grey (PAG). We sought therefore to identify neural adaptations in the PAG, 6 days following chronic constriction injury (CCI), the time at which rats in which disabilities persist are first distinguished from those without disabilities (i.e., No Disability and Transient Disability). GeneChips, RT-PCR and Western blotting revealed the select up-regulation in translation and transcription of glial fibrillary acidic protein (GFAP) and Vimentin in rats with Persistent Disability. Significant increases in GFAP immunoreactivity were localized histologically t...Continue Reading

References

Mar 15, 1990·The Journal of Comparative Neurology·D RicheD Menetrey
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Aug 1, 1981·Brain Research Bulletin·F C BaroneI Zarco de Coronado
Sep 1, 1993·Journal of Neurochemistry·D R Marriott, G P Wilkin
Jun 1, 1994·Glia·Y Shao, K D McCarthy
Jan 16, 1998·Acta Physiologica Scandinavica·G E DelanderB B Fredholm
Sep 24, 1999·Pain·Howard L Fields
Jan 12, 2001·The Clinical Journal of Pain·L A MenefeeL Perez-Schwartz
Jul 31, 2001·Trends in Neurosciences·L R WatkinsS F Maier
Nov 8, 2001·European Journal of Pharmacology·M Zimmermann
Dec 18, 2001·European Journal of Pain : EJP·K Meyer-RosbergA Kristofferson
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·K A Keay, R Bandler
Oct 21, 2004·The Journal of Pathology·Milos Pekny, Marcela Pekna
May 3, 2005·European Journal of Pain : EJP·Stanislava Jergova, Dasa Cizkova
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun LuClifford B Saper

❮ Previous
Next ❯

Citations

Aug 26, 2014·Neuroscience and Biobehavioral Reviews·Ipek YalcinMichel Barrot
Sep 7, 2013·Manual Therapy·Annina B SchmidMichel W Coppieters
Mar 19, 2013·European Journal of Pharmacology·Joanna MikaBarbara Przewlocka
Jan 18, 2011·Brain Research·Amteshwar Singh Jaggi, Nirmal Singh
Mar 7, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Pere Boadas-VaelloEnrique Verdú
Apr 28, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Luke A Henderson, Kevin A Keay
Nov 30, 2018·Genes, Brain, and Behavior·Marco R GuimarãesHugo Leite-Almeida
Mar 15, 2018·The Journal of Headache and Pain·James A WaschekSimon Akerman
Feb 2, 2018·The Journal of Orthopaedic and Sports Physical Therapy·Annina B SchmidBrigitte Tampin
Feb 5, 2021·Cells·Sun-Nyoung HwangHyosang Lee
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida
Jun 15, 2021·Frontiers in Psychiatry·James TangGiannina Descalzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.