Anatomy and pathology of the sinus node

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Siew Yen Ho, D Sánchez-Quintana

Abstract

The aim of this study is to review the key features of anatomy of the sinus node of the human sinus node and its pathological variations as reported in the literature and supplemented with our observations. The sinus node is located adjacent to important structures such as the right phrenic nerve and the nodal artery. Although intimately related to its matrix of fibrous tissue, the nodal cells are in contact with atrial myocardium through nodal extensions. Nodal cell numbers decrease with age as part of the normal aging process. Pathological changes include diminished size of node and nodal cell replacement with fibro-fatty tissues. The location of the normal sinus node is well recognised. There is variation in the relationship of the node and its arterial supply to the terminal crest and the cavo-atrial junction.

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Citations

Jan 9, 2016·Progress in Biophysics and Molecular Biology·Thomas A CsepeVadim V Fedorov
Aug 18, 2016·Pacing and Clinical Electrophysiology : PACE·Ammar M KilluSiva K Mulpuru
Mar 7, 2017·The Annals of Thoracic Surgery·Talal Al-AtassiFraser D Rubens
Mar 20, 2018·Journal of Investigative Medicine High Impact Case Reports·Israel UgaldeAlfonso Tolentino
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Jul 11, 2018·Clinical Science·Vanessa Obas, Ramachandran S Vasan
Jun 21, 2020·Journal of Clinical Medicine·Christophe P TeuwenNatasja M S de Groot
Jan 30, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·G GarretN Saoudi
May 1, 2021·Journal of Cardiovascular Development and Disease·Marietta EasterlingMichael Bressan
Apr 20, 2021·Frontiers in Genetics·Michael J WallacePeter J Mohler
May 25, 2021·HeartRhythm Case Reports·Atif AlQubbanyJohn Silberbauer
Jun 15, 2021·Frontiers in Physiology·Konstantin HennisStefanie Fenske
Jul 23, 2021·GeroScience·Sabrina ChoiClaudia M Moreno

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