Anatomy of smooth muscle cells in nonmalignant and malignant human prostate tissue

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Sebastião R TabogaHernandes F Carvalho

Abstract

Differently graded areas of human prostate adenocarcinoma were examined after Masson's trichrome staining or immunohistochemistry for smooth muscle alpha-actin, type IV collagen and laminin. In addition, the ultrastructure of the prostatic smooth muscle cells (SMC) during glandular proliferation and epithelial invasion in selected tumors was studied. The SMC formed a thick layer below the epithelial structures in unaffected areas and were closely associated with each other in homotypic interactions. As the tumor grade increased, the SMC gradually lost interactions with each other and became atrophic. With the growth of the epithelial compartment, the SMC initially segregated to the tumor periphery and the intercellular spaces increased. In high grade tumors, the epithelial cancer cells invaded the spaces between the SMC. Immunohistochemical analysis of the basal membrane revealed increased disruption of the usually thick basal membrane, which became thinner and faintly stained with each of the antibodies used. We conclude that most SMC become atrophic following epithelial invasion in human tumors and that degradation of the basal membrane is an important factor in this process. At the ultrastructural level, different SMC phenot...Continue Reading

References

Jan 1, 1976·Stain Technology·G Cotta-PereiraJ F David-Ferreira
Aug 1, 1979·Experimental and Molecular Pathology·G Tremblay
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·H OkadaS Morii
Oct 1, 1991·The Journal of Endocrinology·P Davies, C L Eaton
Aug 1, 1989·The American Journal of Anatomy·C P Leblond, S Inoue
Jan 1, 1988·Advances in Cancer Research·A van den Hooff
Jan 1, 1995·Acta Anatomica·M Flug, P Köpf-Maier
Feb 11, 1999·The Prostate·W E Farnsworth
Dec 10, 2003·Journal of Andrology·Eliane AntonioliHernandes F Carvalho
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Nov 1, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Sarandeep S HujaYan Li
Nov 1, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Chandrashekhar CharavaryamathBaljit Singh
May 25, 2007·Journal of Andrology·Eliane AntonioliHernandes F Carvalho

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Citations

Jan 3, 2013·Journal of Cellular Physiology·Carolina LeimgruberCristina Alicia Maldonado
May 11, 2011·The Prostate·Carolina LeimgruberCristina A Maldonado
Aug 17, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Sarah J Holdsworth-CarsonPeter A W Rogers
Mar 12, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Daniel A OsórioHernandes F Carvalho
Jul 14, 2021·The Prostate·Bruno D A SanchesSebastião R Taboga

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