ANCA-associated vasculitis after COVID-19.

Rheumatology International
Tugba Izci DuranNurol Arik

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are systemic autoimmune diseases that may lead to renal failure due to the infiltration of mononuclear cells and the destruction of small- and medium-sized blood vessels. It has been shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger the presentation or exacerbation of autoimmune diseases. Crescentic glomerulonephritis (GN) has rarely been reported in patients with Coronavirus disease-2019 (COVID-19). We present rare two cases with AAV after a recent diagnosis of COVID-19. The first case was 26-year-old male patient, who was presented with acute kidney injury after COVID-19. Serum creatinine increased and active urine sediment was seen. Serological evaluation showed anti-myeloperoxidase antibody was at a level of 80.6 U/mL. Kidney biopsy showed necrotizing GN with cellular crescents. Methylprednisolone, cyclophosphamide and plasma exchange were administered. He was discharged with hemodialysis. Second case was a 36-year-old female who was hospitalized because of fever, cough and dyspnea. After she was diagnosed with COVID-19, she had total hearing loss, with cavitary lesions on bilateral lung parenchyma and an acute kidney in...Continue Reading

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Citations

Jul 20, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Muhammad Tariq ShakoorMatthew Lynch
Aug 25, 2021·Rheumatology International·Chirag Rajkumar KoppAman Sharma
Aug 26, 2021·QJM : Monthly Journal of the Association of Physicians·Tomohiro TakenakaMichi Kawamoto
Aug 1, 2021·Thrombosis and Haemostasis·Toshiaki IbaMarcel Levi

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